Kim Do Young, Park Ella Seo Yeon, Park Hyunjin, Kim Bo Yi, Jun Ikhyun, Seo Kyoung Yul, Elsheikh Ahmed, Kim Tae-Im
Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
J Clin Med. 2025 Jul 14;14(14):4967. doi: 10.3390/jcm14144967.
A new, purely refractive extended depth-of-focus (EDOF) intraocular lens (IOL) was designed with a continuous change in power to bridge the gap between monofocal and multifocal IOLs. This study aimed to evaluate the real-world clinical outcomes of the new EDOF IOL compared with those of the enhanced monofocal IOL. A retrospective analysis was conducted on 100 eyes from 50 patients undergoing bilateral cataract surgery with either the PureSee™ EDOF (ZEN00V) or Eyhance™ (ICB00) monofocal IOL at a single institution. Visual acuity, defocus curves, contrast sensitivity, and patient-reported outcomes were evaluated three months postoperatively. The ZEN00V group demonstrated superior uncorrected intermediate (0.11 ± 0.08 vs. 0.17 ± 0.11 logMAR, = 0.006) and near visual acuity (0.25 ± 0.08 vs. 0.31 ± 0.13 logMAR, = 0.023) compared to the ICB00 group, with comparable distance visual acuity. Both groups exhibited comparable defocus curves and contrast sensitivity. While photic phenomena were more frequent in the ZEN00V group, spectacle dependence was significantly lower for near vision (36% vs. 80%, = 0.002) and comparable for intermediate and far vision. The PureSee™ EDOF IOL demonstrated enhanced intermediate and near vision with minimal compromise to distance vision while maintaining high contrast sensitivity. It also offered significant spectacle independence and patient satisfaction, making it a promising option for presbyopia correction.
一种新型的、纯折射的扩展景深（EDOF）人工晶状体（IOL）被设计出来，其屈光力连续变化，以弥合单焦点和多焦点IOL之间的差距。本研究旨在评估新型EDOF IOL与增强型单焦点IOL相比的实际临床效果。对在单一机构接受双侧白内障手术的50例患者的100只眼睛进行了回顾性分析，这些患者分别植入了PureSee™ EDOF（ZEN00V）或Eyhance™（ICB00）单焦点IOL。术后三个月评估视力、散焦曲线、对比敏感度和患者报告的结果。与ICB00组相比，ZEN00V组在未矫正的中视力（0.11±0.08 vs. 0.17±0.11 logMAR，P = 0.006）和近视力（0.25±0.08 vs. 0.31±0.13 logMAR，P = 0.023）方面表现更优，远视力相当。两组的散焦曲线和对比敏感度相当。虽然ZEN00V组的光现象更频繁，但近视力的眼镜依赖度显著更低（36% vs. 80%，P = 0.002），中视力和远视力的眼镜依赖度相当。PureSee™ EDOF IOL在对远视力影响最小的情况下增强了中视力和近视力，同时保持了高对比敏感度。它还提供了显著的无眼镜独立性和患者满意度，使其成为矫正老花眼的一个有前景的选择。
