Wei Shu-Yi, Wu Zhen, Xu Yao, Li Dan, Xia Yimin
Department of Ophthalmology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, China.
Department of Ear, Nose, and Throat, Changshu No. 2 People's Hospital/Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, China.
Sleep Breath. 2025 Jul 29;29(4):254. doi: 10.1007/s11325-025-03405-0.
To analyze the effect of mask usage on dry eye symptoms and meibomian gland function in patients with obstructive sleep apnea syndrome (OSAS).
OSAS patients who visited our hospital from January 2022 to December 2023 were selected as research subjects. All patients were treated with continuous positive airway pressure (CPAP) therapy. The polysomnography (PSG) results before and after treatment were analyzed, including the apnea-hypopnea index (AHI) and peripheral oxygen saturation (SpO). Dry eye conditions and ocular surface analyzer results of patients before and after treatment were evaluated. Pearson correlation was used to assess the relationship between dry eye conditions and ocular surface analyzer results in OSAS patients, and the correlations between PSG results and dry eye conditions as well as ocular surface analyzer results were also analyzed.
AHI levels in 31 OSAS patients were significantly decreased after treatment, while SpO levels significantly increased, with a statistically significant difference (P<0.05). After treatment, the tear breakup time (BUT), palpebral (PL) scores, and Ocular Surface Disease Index (OSDI) scores of patients were significantly higher than those before treatment (P<0.05). Additionally, after treatment, the tear meniscus height of OSAS patients was significantly lower than that before treatment, and the lipid layer thickness and eye redness index were significantly higher than those before treatment, with a statistically significant difference (P<0.05). The results of Pearson correlation analysis showed that BUT was positively correlated with lipid layer thickness and eye redness improvement, while Schirmer's test (Sit) was positively correlated with tear meniscus height. PL scores were negatively correlated with tear meniscus height but positively correlated with the eye redness index (P<0.05). AHI from PSG results was negatively correlated with BUT, PL scores, and OSDI scores (P<0.05), while SpO was positively correlated with BUT, PL scores, and OSDI scores but negatively correlated with Sit (P<0.05). In the PSG results, AHI was negatively correlated with lipid layer thickness and eye redness index, and positively correlated with meibomian gland opening score (P < 0.05).
CPAP mask usage in OSAS patients may negatively impact dry eye symptoms and meibomian gland function, leading to decreased tear film stability and worsening symptoms of eye dryness.
分析面罩使用对阻塞性睡眠呼吸暂停综合征（OSAS）患者干眼症状及睑板腺功能的影响。
选取2022年1月至2023年12月来我院就诊的OSAS患者作为研究对象。所有患者均接受持续气道正压通气（CPAP）治疗。分析治疗前后的多导睡眠图（PSG）结果，包括呼吸暂停低通气指数（AHI）和外周血氧饱和度（SpO）。评估患者治疗前后的干眼情况及眼表分析仪结果。采用Pearson相关性分析评估OSAS患者干眼情况与眼表分析仪结果之间的关系，同时分析PSG结果与干眼情况及眼表分析仪结果之间的相关性。
31例OSAS患者治疗后AHI水平显著降低，SpO水平显著升高，差异有统计学意义（P<0.05）。治疗后，患者的泪膜破裂时间（BUT）、睑裂（PL）评分及眼表疾病指数（OSDI）评分均显著高于治疗前（P<0.05）。此外，治疗后OSAS患者的泪河高度显著低于治疗前，脂质层厚度及眼红指数显著高于治疗前，差异有统计学意义（P<0.05）。Pearson相关性分析结果显示，BUT与脂质层厚度及眼红改善情况呈正相关，而泪液分泌试验（Sit）与泪河高度呈正相关。PL评分与泪河高度呈负相关，但与眼红指数呈正相关（P<0.05）。PSG结果中的AHI与BUT、PL评分及OSDI评分呈负相关（P<0.05），而SpO与BUT、PL评分及OSDI评分呈正相关，但与Sit呈负相关（P<0.05）。在PSG结果中，AHI与脂质层厚度及眼红指数呈负相关，与睑板腺开口评分呈正相关（P < 0.05）。
OSAS患者使用CPAP面罩可能会对干眼症状及睑板腺功能产生负面影响，导致泪膜稳定性下降及干眼症状加重。
