Angel E, Davis J R, Nagle R B
Am J Clin Pathol. 1985 Dec;84(6):705-9. doi: 10.1093/ajcp/84.6.705.
The authors find that immunohistochemical demonstration of placental hormones in endometrium is useful in the identification of trophoblast independent of the presence of chorionic villi. Human chorionic gonadotropin (HCG) and human placental lactogen (HPL) are markers for trophoblastic cells. The markers were studied in 21 cases of gestational endometrium without villi in which the clinical differential diagnosis was ectopic pregnancy versus missed or incomplete uterine abortion. Trophoblastic cells were identified in four cases by routine microscopy and in an additional seven cases using the markers. In none of these cases was there a subsequent demonstration of ectopic pregnancy. In six of the ten negative cases, ectopic pregnancies subsequently were removed. Thus, the use of these hormone markers in endometrial specimens increases precision in the diagnosis of uterine versus ectopic pregnancy.
作者发现，子宫内膜中胎盘激素的免疫组化显示有助于在不依赖绒毛膜绒毛存在的情况下识别滋养层细胞。人绒毛膜促性腺激素（HCG）和人胎盘催乳素（HPL）是滋养层细胞的标志物。对21例无绒毛的妊娠子宫内膜病例进行了这些标志物的研究，这些病例的临床鉴别诊断为异位妊娠与稽留流产或不完全流产。通过常规显微镜检查在4例中鉴定出滋养层细胞，另外7例使用标志物鉴定出滋养层细胞。在这些病例中均未随后证实为异位妊娠。在10例阴性病例中的6例中，随后切除了异位妊娠组织。因此，在子宫内膜标本中使用这些激素标志物可提高子宫妊娠与异位妊娠诊断的准确性。
