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基于Transformer的皮肤电活动分解在现实世界心理健康应用中的研究

Transformer-Based Decomposition of Electrodermal Activity for Real-World Mental Health Applications.

作者信息

Tsirmpas Charalampos, Konstantopoulos Stasinos, Andrikopoulos Dimitris, Kyriakouli Konstantina, Fatouros Panagiotis

机构信息

Feel Therapeutics Inc., San Francisco, CA 94108, USA.

Siglyx, 151 22 Athens, Greece.

出版信息

Sensors (Basel). 2025 Jul 15;25(14):4406. doi: 10.3390/s25144406.


DOI:10.3390/s25144406
PMID:40732534
Abstract

Decomposing Electrodermal Activity (EDA) into phasic (short-term, stimulus-linked responses) and tonic (longer-term baseline) components is essential for extracting meaningful emotional and physiological biomarkers. This study presents a comparative analysis of knowledge-driven, statistical, and deep learning-based methods for EDA signal decomposition, with a focus on in-the-wild data collected from wearable devices. In particular, the authors introduce the Feel Transformer, a novel Transformer-based model adapted from the Autoformer architecture, designed to separate phasic and tonic components without explicit supervision. The model leverages pooling and trend-removal mechanisms to enforce physiologically meaningful decompositions. Comparative experiments against methods such as Ledalab, cvxEDA, and conventional detrending show that the Feel Transformer achieves a balance between feature fidelity (SCR frequency, amplitude, and tonic slope) and robustness to noisy, real-world data. The model demonstrates potential for real-time biosignal analysis and future applications in stress prediction, digital mental health interventions, and physiological forecasting.

摘要

将皮肤电活动(EDA)分解为相位成分(短期、与刺激相关的反应)和紧张性成分(长期基线)对于提取有意义的情绪和生理生物标志物至关重要。本研究对基于知识驱动、统计和深度学习的EDA信号分解方法进行了比较分析,重点关注从可穿戴设备收集的实际环境数据。特别是,作者介绍了Feel Transformer,这是一种基于Transformer架构改编的新型模型,旨在在无明确监督的情况下分离相位和紧张性成分。该模型利用池化和趋势消除机制来实现具有生理意义的分解。与Ledalab、cvxEDA等方法以及传统去趋势方法的对比实验表明,Feel Transformer在特征保真度(皮肤电反应频率、幅度和紧张性斜率)与对嘈杂的真实世界数据的鲁棒性之间取得了平衡。该模型展示了实时生物信号分析以及在压力预测、数字心理健康干预和生理预测等未来应用中的潜力。

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本文引用的文献

[1]
Randomized controlled study of a digital data driven intervention for depressive and generalized anxiety symptoms.

NPJ Digit Med. 2025-2-19

[2]
Machine learning-enabled detection of attention-deficit/hyperactivity disorder with multimodal physiological data: a case-control study.

BMC Psychiatry. 2024-8-5

[3]
Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study.

Transl Psychiatry. 2024-2-3

[4]
A Digital Mental Health Support Program for Depression and Anxiety in Populations With Attention-Deficit/Hyperactivity Disorder: Feasibility and Usability Study.

JMIR Form Res. 2023-10-11

[5]
Does Wearable-Measured Heart Rate Variability During Sleep Predict Perceived Morning Mental and Physical Fitness?

Appl Psychophysiol Biofeedback. 2023-6

[6]
Feasibility, engagement, and preliminary clinical outcomes of a digital biodata-driven intervention for anxiety and depression.

Front Digit Health. 2022-7-22

[7]
Electrodermal Activity for Measuring Cognitive and Emotional Stress Level.

J Med Signals Sens. 2022-5-12

[8]
Assessment of Resilience of the Hellenic Navy Seals by Electrodermal Activity during Cognitive Tasks.

Int J Environ Res Public Health. 2021-4-20

[9]
Validating Measures of Electrodermal Activity and Heart Rate Variability Derived From the Empatica E4 Utilized in Research Settings That Involve Interactive Dyadic States.

Front Behav Neurosci. 2020-8-18

[10]
Skin Conductance as a Viable Alternative for Closing the Deep Brain Stimulation Loop in Neuropsychiatric Disorders.

Front Neurosci. 2019-8-7

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