Curtis R J, Delee J C, Drez D J
Am J Sports Med. 1985 Nov-Dec;13(6):408-14. doi: 10.1177/036354658501300608.
In 16 adult dogs the anterior cruciate ligament (ACL) was transected and then reconstructed using freeze dried fascia lata allografts. Eight of the dogs had the intraarticular graft passed through drill holes in the tibia and femur, while in the other eight dogs the graft was passed through a drill hole in the tibia and routed "over-the-top" of the lateral femoral condyle. In all dogs the grafts were then passed deep to the lateral collateral ligament and secondarily secured to the tibia as an extraarticular reconstruction. Specimens from each group underwent histologic study and biomechanical testing on a mechanical testing system at 3, 6, 12, and 24 week intervals. All grafts were found to be intact at sacrifice with no overt evidence of biologic incompatibility. The knees displayed only mild instability to clinical testing without evidence of arthrosis. Histologically, the grafts appeared to function as a collagenous scaffolding for revascularization and fibrovascular creeping substitution. The mean maximum load at failure in the 24 week specimens reached 536.44 N, compared to values of 801.85 N in contralateral knees with an intact ACL.
在16只成年犬中，切断前交叉韧带（ACL），然后使用冻干同种异体阔筋膜进行重建。其中8只犬的关节内移植物穿过胫骨和股骨的钻孔，而另外8只犬的移植物穿过胫骨的钻孔并经股骨外侧髁“过顶”穿出。在所有犬中，移植物随后穿过外侧副韧带深层，并作为关节外重建再次固定于胫骨。每组样本在术后3、6、12和24周时进行组织学研究，并在力学测试系统上进行生物力学测试。处死时发现所有移植物均完整，无明显生物不相容的证据。膝关节在临床检查时仅表现为轻度不稳定，无关节病迹象。组织学上，移植物似乎起到了胶原支架的作用，促进血管再生和纤维血管的缓慢替代。24周样本的平均最大破坏载荷达到536.44 N，而对侧ACL完整的膝关节该值为801.85 N。
