McNulty C A, Garden G M, Ashby J, Wise R
Antimicrob Agents Chemother. 1985 Sep;28(3):425-7. doi: 10.1128/AAC.28.3.425.
The pharmacokinetics of the monobactam carumonam (Ro 17-2301) as derived from serial measurement of the concentrations of this agent in serum, blister fluid, and urine were studied in six male volunteers subsequent to intravenous infusion of a single 2-g dose. Drug levels in serum in excess of 75 micrograms/ml were achieved 0.5 h after the end of infusion, declining to 2.9 micrograms/ml at 8 h. The mean serum and blister fluid elimination half-lives were 1.68 and 1.7 h, respectively. The urinary recovery of the drug by 24 h was 80.6% (range, 68.3 to 91.1%). Carumonam penetrated blister fluid well, the mean percentage penetration (as measured by the ratio of areas under curves) being 101.6%.
在6名男性志愿者静脉输注单次2克剂量后，通过连续测定血清、水疱液和尿液中单环β-内酰胺类药物卡芦莫南（Ro 17 - 2301）的浓度，研究了其药代动力学。输注结束后0.5小时血清药物水平超过75微克/毫升，8小时时降至2.9微克/毫升。血清和水疱液的平均消除半衰期分别为1.68小时和1.7小时。24小时药物经尿液回收量为80.6%（范围为68.3%至91.1%）。卡芦莫南能很好地渗透入水疱液，平均渗透百分比（通过曲线下面积比测量）为101.6%。
