Amir Momina, Rosa Maria Atalaia, Debeer Lina, Vercooren Nadalan, Franceschini Filippo, Van Den Eeckhoudt Ruben, Kuznetsova Nadezda, Kraft Michael, Taurino Irene
Department of Electrical Engineering (Micro- and Nano Systems), KU Leuven - University of Leuven, Leuven, 3001, Belgium.
Department of Electrical Engineering (Micro- and Nano Systems), KU Leuven - University of Leuven, Leuven, 3001, Belgium.
Biosens Bioelectron. 2025 Nov 15;288:117806. doi: 10.1016/j.bios.2025.117806. Epub 2025 Jul 23.
Microneedles are revolutionizing healthcare by enabling minimally invasive drug delivery and real-time biosensing. This study presents an innovative polymer-based wearable system that integrates SU-8 microneedle arrays with a flexible, stretchable substrate, ensuring close skin conformity. Using a single-step backside lithography technique, we fabricated 3D microneedles, followed by a simplified etching process to produce nanostructured surfaces that enhance sensing functionality. The patch supports metal and dielectric deposition, enabling versatile sensing configurations. As a proof of concept, the device demonstrated reproducible performance for hydrogen peroxide electrochemical sensing. Tests on a skin mimic model confirmed its ability to penetrate successfully, as predicted by simulations. This scalable, cleanroom-compatible technology represents a significant advancement in microneedle-based diagnostics, paving the way for practical and minimally invasive healthcare solutions.
微针通过实现微创给药和实时生物传感，正在彻底改变医疗保健行业。本研究提出了一种创新的基于聚合物的可穿戴系统，该系统将SU-8微针阵列与柔性、可拉伸的基底集成在一起，确保与皮肤紧密贴合。我们采用单步背面光刻技术制造了3D微针，随后通过简化的蚀刻工艺制备出增强传感功能的纳米结构表面。该贴片支持金属和电介质沉积，可实现多种传感配置。作为概念验证，该设备在过氧化氢电化学传感方面表现出可重复的性能。在皮肤模拟模型上的测试证实了其如模拟预测的那样成功穿透的能力。这种可扩展的、与洁净室兼容的技术代表了基于微针的诊断技术的重大进步，为实用的微创医疗保健解决方案铺平了道路。
