非洛地平对正常男性前臂血流动力学及前臂阻力血管肌源性反应的影响。
The effect of felodipine on forearm haemodynamics and the myogenic response of the forearm resistance vessels in normal man.
作者信息
Mace P J, Stallard T J, Littler W A
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):383-6. doi: 10.1111/j.1365-2125.1985.tb05081.x.
The effect of felodipine 10 mg oral solution or placebo on peripheral haemodynamics and the response of the forearm resistance vessels to venous occlusion was studied in seven normotensive individuals. Felodipine produced a significant fall in diastolic blood pressure (DBP max = -15 mm Hg), a rise in heart rate (heart rate max = +15 beats min-1) (both P less than 0.01), and an overall fall in calculated forearm vascular resistance (calculated forearm vascular resistance max = -19.6 units, P less than 0.001). Felodipine had no significant effect on the vasodilator response, but limited the vasoconstrictor response following venous occlusion. These observations suggest that felodipine is a potent vasodilator and interferes with the myogenic response of vascular smooth muscle of the forearm resistance vessels.
在7名血压正常的个体中，研究了非洛地平10mg口服溶液或安慰剂对外周血流动力学以及前臂阻力血管对静脉闭塞反应的影响。非洛地平使舒张压显著下降（舒张压最大降幅=-15mmHg），心率上升（心率最大增幅=+15次/分钟）（两者P均<0.01），且计算得出的前臂血管阻力总体下降（计算得出的前臂血管阻力最大降幅=-19.6单位，P<0.001）。非洛地平对血管舒张反应无显著影响，但限制了静脉闭塞后的血管收缩反应。这些观察结果表明，非洛地平是一种强效血管舒张剂，会干扰前臂阻力血管血管平滑肌的肌源性反应。
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