Rostami Samira, Bermudo-Gallaguet Adrià, Camins-Vila Neus, Ferrer-Uris Blai, Busquets Albert, Ribera Mireia, Coll Laura, Gallego Vila Jaime, Oliva Martínez Ramon, Slater Mel, Garcia Diez Gustavo, Perales Castellanos Nazareth, Larrosa Mar, Bielsa-Pascual Jofre, Torán-Montserrat Pere, Bruna Rabassa Olga, Guerra-Balic Myriam, Erickson Kirk I, Brown Belinda, Serrat Maria Mataró
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Institute of Neuroscience, University of Barcelona, Barcelona, Spain.
PLoS One. 2025 Aug 1;20(8):e0328538. doi: 10.1371/journal.pone.0328538. eCollection 2025.
BACKGROUND: Mental health issues among young university students have increased in recent years, driven by academic stress and sedentary lifestyles. The YoungFitT Project aims to explore well-being strategies and the psychobiological mechanisms behind their effects on university students. The project includes two studies: the first evaluates the effectiveness of High-Intensity Functional Training (HIFT), Mindfulness-Based Stress Reduction (MBSR), and Qigong (QG) on psychological well-being and cognitive functions, and also explores whether socio-demographic, mental (mindful thinking, sleep quality), physical (physical fitness, physical activity), physiological (heart rate variability), and biological (microbiota) factors mediate or moderate intervention effects on university students. Given that immersive virtual reality (VR) can enhance adherence and provide additional benefits, the second study will explore the feasibility and efficacy of HIFT-VR, MBSR-VR, and QG-VR on university students' psychological well-being and cognitive functions. METHODS: Two mixed-methods randomized controlled trials will be conducted. In Study 1, participants will be randomly assigned to one of three groups (HIFT, MBSR, QG) using a 1:1:1 ratio. Psychological, cognitive, physical, physiological, and biological measures will be evaluated two weeks before and after the interventions. The interventions include three weekly sessions for 12 weeks. Subsequently, a follow-up will be conducted 12 weeks after the intervention to assess psychological well-being. Study 2 is a proof-of-concept study in which VR interventions will be co-designed with input from university students and professionals. Twelve participants from each study will also complete semi-structured interviews to explore their experiences and perceived impact. DISCUSSION: The proposed interventions are expected to produce differential effects on psychological well-being and cognitive function. VR environments may enhance adherence and offer added benefits over conventional training. Findings will inform effective, personalized strategies for the mental and physical health of university youth. TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier NCT06406283; Registration date: 2024/05/06.
背景：近年来，受学业压力和久坐不动生活方式的影响，青年大学生的心理健康问题有所增加。YoungFitT项目旨在探索促进幸福感的策略及其对大学生产生影响背后的心理生物学机制。该项目包括两项研究：第一项评估高强度功能训练（HIFT）、基于正念减压疗法（MBSR）和气功（QG）对心理健康和认知功能的有效性，同时探讨社会人口统计学、心理（正念思维、睡眠质量）、身体（身体素质、身体活动）、生理（心率变异性）和生物学（微生物群）因素是否介导或调节对大学生的干预效果。鉴于沉浸式虚拟现实（VR）可以提高依从性并带来额外益处，第二项研究将探索HIFT-VR、MBSR-VR和QG-VR对大学生心理健康和认知功能的可行性和有效性。 方法：将进行两项混合方法随机对照试验。在研究1中，参与者将以1:1:1的比例随机分配到三个组（HIFT、MBSR、QG）之一。在干预前后两周对心理、认知、身体、生理和生物学指标进行评估。干预包括每周三次，共12周。随后，在干预后12周进行随访，以评估心理健康状况。研究2是一项概念验证研究，其中VR干预将在大学生和专业人员的参与下共同设计。每项研究的12名参与者还将完成半结构化访谈，以探索他们的经历和感知到的影响。 讨论：预期所提议的干预措施将对心理健康和认知功能产生不同的影响。VR环境可能会提高依从性，并比传统训练带来更多益处。研究结果将为促进大学青年身心健康的有效、个性化策略提供依据。 试验注册：www.ClinicalTrials.gov，标识符NCT06406283；注册日期：2024年5月6日。
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