Annam Suresh Chandra V A R, Elbermawi Ahmed, Huh Jungmoo, Zhang Jin, Ali Zulfiqar, Khan Ikhlas A, Pugh Nirmal D, Chittiboyina Amar G
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University MS, 38677, United States.
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University MS, 38677, United States; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University MS, 38677, United States.
Bioorg Med Chem Lett. 2025 Dec 1;128:130358. doi: 10.1016/j.bmcl.2025.130358. Epub 2025 Aug 5.
Previously, a chemical standardization method quantifying six fatty acids was established for Limnospira (formerly Arthrospira) authenticity and quality control. Since glyceroglycolipids constitute a significant source of fatty acids in Limnospira, a targeted phytochemical investigation was performed that resulted in the identification of two novel diacylated glycerol sulfoquinvosides and four known compounds. Notably, in vitro anti-influenza activity of isolated and analogous glyceroglycolipids, specifically two glyceroglycolipids, incorporating γ-linolenic acid and sulfoquinvose units tethered to a glycerol backbone, exhibited the highest anti-influenza activity. These findings suggest that the glyceroglycolipid-enriched fraction from Limnospira holds the potential for direct-acting antiviral properties.
此前，已建立了一种定量六种脂肪酸的化学标准化方法，用于螺旋藻（原节旋藻）的真伪鉴定和质量控制。由于甘油糖脂是螺旋藻中脂肪酸的重要来源，因此开展了一项靶向植物化学研究，结果鉴定出两种新型二酰化甘油磺基喹喔糖苷和四种已知化合物。值得注意的是，分离得到的甘油糖脂及其类似物，特别是两种含有γ-亚麻酸和连接在甘油主链上的磺基喹喔糖单元的甘油糖脂，其体外抗流感活性最高。这些发现表明，螺旋藻中富含甘油糖脂的部分具有直接抗病毒特性的潜力。
