Hyoudou Tomoka, Hirose Yoshie, Fujita Chiharu, Inoue Hajime
Dermatology, Ginza Yoshie Clinic, Tokyo, JPN.
Regenerative Medicine, Laboratory of Cell Applied Technologies Co., Tokyo, JPN.
Cureus. 2025 Jul 4;17(7):e87296. doi: 10.7759/cureus.87296. eCollection 2025 Jul.
Acne vulgaris often results in disfigurement with scarring if early treatment is insufficient. In particular, tissue destruction due to infection of hair follicles leads to contracture. There are many treatments for acne scars and scar contracture, but therapy of scar contracture, especially ice pick-like scars or crater-shaped scars, is difficult. In this study, we attempted treatment with grafting of an autologous cultured epithelial sheet in four patients with acne vulgaris accompanied by scar contracture. As a result, not only was the scarring improved, but the skin texture was also improved in all cases three months after grafting. Excessive collagen synthesis during the healing process following tissue destruction induces scar contracture, but various proteases secreted by the grafted cultured epithelium are thought to metabolize this excess collagen, improving the scarring and skin texture. Autologous cultured epithelium grafting, which can be completed with a single treatment, may be an effective method for treating acne scars.
寻常痤疮若早期治疗不充分，常导致毁容及瘢痕形成。特别是毛囊感染引起的组织破坏会导致挛缩。痤疮瘢痕和瘢痕挛缩有多种治疗方法，但瘢痕挛缩的治疗，尤其是冰锥样瘢痕或火山口样瘢痕的治疗很困难。在本研究中，我们尝试对4例伴有瘢痕挛缩的寻常痤疮患者进行自体培养上皮片移植治疗。结果，移植后3个月，所有病例不仅瘢痕得到改善，皮肤质地也得到改善。组织破坏后愈合过程中过量的胶原蛋白合成会导致瘢痕挛缩，但移植的培养上皮分泌的各种蛋白酶被认为可代谢这种过量的胶原蛋白，从而改善瘢痕和皮肤质地。自体培养上皮移植可通过单次治疗完成，可能是治疗痤疮瘢痕的有效方法。
