• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫球蛋白序列变异性的结构影响

Structural implications of sequence variability in immunoglobulins.

作者信息

Padlan E A

出版信息

Proc Natl Acad Sci U S A. 1977 Jun;74(6):2551-5. doi: 10.1073/pnas.74.6.2551.

DOI:10.1073/pnas.74.6.2551
PMID:407580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432211/
Abstract

Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to be involved in hapten binding.

摘要

通过使用一种考虑氨基酸物理化学性质差异的技术来比较免疫球蛋白序列。外部残基比内部残基表现出更大的结构变异性。在晶体学研究已知参与半抗原结合的位置发现了高结构变异性。

相似文献

1
Structural implications of sequence variability in immunoglobulins.免疫球蛋白序列变异性的结构影响
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2551-5. doi: 10.1073/pnas.74.6.2551.
2
Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity.λ轻链可变区与连接区边界处的多样性对免疫球蛋白配体结合活性有显著影响。
Proc Natl Acad Sci U S A. 1984 Oct;81(19):6139-43. doi: 10.1073/pnas.81.19.6139.
3
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus species.分析来自单峰驼和双峰驼的常规骆驼抗体的重链和轻链序列。
J Immunol Methods. 2014 Mar;405:35-46. doi: 10.1016/j.jim.2014.01.003. Epub 2014 Jan 18.
4
The response of rabbits to streptococcal hyperimmunization.
Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:689-98. doi: 10.1101/sqb.1977.041.01.079.
5
Allotypic markers.同种异型标记
Monogr Allergy. 1986;19:40-51.
6
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes.小鼠免疫球蛋白重链由多个种系可变区基因编码。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4096-100. doi: 10.1073/pnas.71.10.4096.
7
Immunoglobulin disulfide bridges: theme and variations.免疫球蛋白二硫键：主题与变体
Biosci Rep. 1985 Oct-Nov;5(10-11):973-89. doi: 10.1007/BF01119910.
8
Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies.人和鼠免疫球蛋白Fv结构域中表面可及残基的比较。对鼠源抗体人源化的启示。
J Mol Biol. 1994 Jan 21;235(3):959-73. doi: 10.1006/jmbi.1994.1050.
9
A molecular hybridization approach for the determination of the immunoglobulin V-gene pool size.
Immunol Rev. 1977;36:29-50. doi: 10.1111/j.1600-065x.1977.tb00381.x.
10
Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2.同种异型α2抗肺炎球菌免疫球蛋白重链N端区域的部分氨基酸序列
Biochem J. 1974 Apr;139(1):281-3. doi: 10.1042/bj1390281.

引用本文的文献

1
Engineered hapten-binding antibody derivatives for modulation of pharmacokinetic properties of small molecules and targeted payload delivery.用于调节小分子药代动力学特性和靶向载荷递送的工程化半抗原结合抗体衍生物。
Immunol Rev. 2016 Mar;270(1):165-77. doi: 10.1111/imr.12386.
2
Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure.Paratome：一种基于序列或结构的系统识别抗体抗原结合区域的在线工具。
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W521-4. doi: 10.1093/nar/gks480. Epub 2012 Jun 6.
3
Antibodies designed as effective cancer vaccines.设计用于癌症治疗的有效疫苗的抗体。
MAbs. 2009 Jan-Feb;1(1):71-85. doi: 10.4161/mabs.1.1.7492.
4
Interaction between the antigen and antibody is controlled by the constant domains: normal mode dynamics of the HEL-HyHEL-10 complex.抗原与抗体之间的相互作用由恒定结构域控制：HEL-HyHEL-10复合物的正常模式动力学。
Protein Sci. 2003 Oct;12(10):2125-31. doi: 10.1110/ps.03100803.
5
H-2Dd exploits a four residue peptide binding motif.H-2Dd利用一个四残基肽结合基序。
J Exp Med. 1993 Dec 1;178(6):1877-92. doi: 10.1084/jem.178.6.1877.
6
A mimotope from a solid-phase peptide library induces a measles virus-neutralizing and protective antibody response.来自固相肽库的模拟表位可诱导麻疹病毒中和及保护性抗体反应。
J Virol. 1995 Dec;69(12):7668-73. doi: 10.1128/JVI.69.12.7668-7673.1995.
7
Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.三种抗溶菌酶单克隆抗体结合位点及其一种抗体与其表位之间复合物的建模。
EMBO J. 1986 Feb;5(2):415-25. doi: 10.1002/j.1460-2075.1986.tb04227.x.
8
Immunogenic peptides of influenza virus subtype N1 neuraminidase identify a T-cell determinant used in class II major histocompatibility complex-restricted responses to infectious virus.甲型流感病毒N1神经氨酸酶的免疫原性肽段鉴定出一种用于II类主要组织相容性复合体限制的针对感染性病毒应答的T细胞决定簇。
J Virol. 1991 Feb;65(2):672-6. doi: 10.1128/JVI.65.2.672-676.1991.
9
Patterns of interallelic divergence at the rabbit b-locus of the immunoglobulin light chain constant region are in agreement with population genetical evidence for overdominant selection.免疫球蛋白轻链恒定区兔b位点的等位基因间差异模式与超显性选择的群体遗传学证据一致。
Genetics. 1992 Dec;132(4):1105-17. doi: 10.1093/genetics/132.4.1105.

本文引用的文献

1
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
J Exp Med. 1970 Aug 1;132(2):211-50. doi: 10.1084/jem.132.2.211.
2
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.尝试在轻链和重链可变区定位互补决定残基。
Ann N Y Acad Sci. 1971 Dec 31;190:382-93. doi: 10.1111/j.1749-6632.1971.tb13550.x.
3
Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.由本斯-琼斯蛋白REI可变部分组成的二聚体的晶体结构和分子结构
Eur J Biochem. 1974 Jun 15;45(2):513-24. doi: 10.1111/j.1432-1033.1974.tb03576.x.
4
Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer.2,4-二硝基苯基化合物及其他小分子与一种结晶λ型本斯-琼斯二聚体的结合
Biochemistry. 1974 Aug 27;13(18):3816-27. doi: 10.1021/bi00715a031.
5
Amino acid difference formula to help explain protein evolution.有助于解释蛋白质进化的氨基酸差异公式。
Science. 1974 Sep 6;185(4154):862-4. doi: 10.1126/science.185.4154.862.
6
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.一种结合磷酸胆碱的小鼠免疫球蛋白Fab的三维结构及抗原结合位点的性质。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4298-302. doi: 10.1073/pnas.71.11.4298.
7
Amino-acid sequence of an allotype b4 light chain from a rabbit antibody to streptococcal carbohydrate.来自兔抗链球菌碳水化合物抗体的同种异型b4轻链的氨基酸序列。
Proc Natl Acad Sci U S A. 1974 May;71(5):1995-8. doi: 10.1073/pnas.71.5.1995.
8
The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.免疫球蛋白 NEW 结合区域 - 配体复合物在 3.5 埃分辨率下的三维结构。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1427-30. doi: 10.1073/pnas.71.4.1427.
9
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.VH3亚组的五条人免疫球蛋白重链的可变区序列：四个重链高变区的明确鉴定
Proc Natl Acad Sci U S A. 1974 Mar;71(3):845-8. doi: 10.1073/pnas.71.3.845.
10
Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution.人免疫球蛋白Fab'片段在2.8埃分辨率下的三维结构。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3305-10. doi: 10.1073/pnas.70.12.3305.