免疫球蛋白序列变异性的结构影响
Structural implications of sequence variability in immunoglobulins.
作者信息
Padlan E A
出版信息
Proc Natl Acad Sci U S A. 1977 Jun;74(6):2551-5. doi: 10.1073/pnas.74.6.2551.
Abstract
Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to be involved in hapten binding.
摘要
通过使用一种考虑氨基酸物理化学性质差异的技术来比较免疫球蛋白序列。外部残基比内部残基表现出更大的结构变异性。在晶体学研究已知参与半抗原结合的位置发现了高结构变异性。
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本文引用的文献
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