同种异型α2抗肺炎球菌免疫球蛋白重链N端区域的部分氨基酸序列
Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2.
作者信息
Jaton J C, Haimovich J
出版信息
Biochem J. 1974 Apr;139(1):281-3. doi: 10.1042/bj1390281.
Abstract
The amino acid sequence of the N-terminal 48 residues of the heavy chain derived from a homogeneous rabbit antibody to type III pneumococci is described. This chain of allotype a(2) is compared with other rabbit heavy chains of allotypes a(1), a(2) and a(3). Within the N-terminal 25 positions, two chains which carry the same allotype a(2) possess identical amino acid sequences, but differ markedly from heavy chains of allotypes a(1) and a(3). Sequence variability is observed in residues 26-27 and 30-34, but not in residues 35-48.
摘要
本文描述了源自针对III型肺炎球菌的纯合兔抗体的重链N端48个残基的氨基酸序列。将这种同种异型a(2)的链与同种异型a(1)、a(2)和a(3)的其他兔重链进行了比较。在N端25个位置内，两条携带相同同种异型a(2)的链具有相同的氨基酸序列，但与同种异型a(1)和a(3)的重链明显不同。在残基26 - 27和30 - 34中观察到序列变异性，但在残基35 - 48中未观察到。
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