Gökaslan Serkan, Yilmaz Ömer Faruk, Korucu Cem, Günlük Necati Berk, Balci Aydin
Department of Cardiology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Emergency Department, Kumluca State Hospital, Antalya, Turkey.
Medicine (Baltimore). 2025 Aug 1;104(31):e43643. doi: 10.1097/MD.0000000000043643.
Coronary artery disease (CAD) is closely associated with endothelial dysfunction and atherosclerosis, characterized by lipid accumulation in large artery walls. The systemic immune-inflammatory index is an emerging biomarker linked to cardiovascular disease progression. Soleus push-up exercises, targeting the soleus muscle (predominantly Type I fibers), may benefit patients with CAD. This study aimed to evaluate the effects of soleus push-up exercises on blood lipid profiles and systemic immune-inflammatory index in CAD patients. Forty-three CAD patients were enrolled and divided into 2 groups: 24 patients in the exercise group performed soleus push-up exercises, while 19 served as the control group with no exercise recommendations. Blood lipid profiles and systemic immune-inflammatory index were measured at baseline, 1 month, and 3 months. At the 1-month follow-up, the exercise group showed significantly lower total cholesterol levels and systemic immune-inflammatory index scores compared to the control group (P < .005). At the 3-month follow-up, the exercise group had significantly higher high-density lipoprotein cholesterol (HDL-C) levels (P < .005), and lower low-density lipoprotein cholesterol (LDL-C) and total cholesterol levels (P < .005) than the control group. The exercise group also exhibited significantly lower systemic inflammatory index (SII) scores at 3 months (P < .001). Soleus push-up exercises may positively influence blood lipid profiles and systemic immune-inflammatory index in CAD patients, highlighting a potential noninvasive approach for managing cardiovascular risk factors.
冠状动脉疾病（CAD）与内皮功能障碍和动脉粥样硬化密切相关，其特征是大动脉壁中脂质堆积。全身免疫炎症指数是一种新兴的生物标志物，与心血管疾病进展相关。针对比目鱼肌（主要是I型纤维）的比目鱼肌俯卧撑运动可能对CAD患者有益。本研究旨在评估比目鱼肌俯卧撑运动对CAD患者血脂谱和全身免疫炎症指数的影响。43例CAD患者入组并分为2组：24例运动组患者进行比目鱼肌俯卧撑运动，19例作为无运动建议的对照组。在基线、1个月和3个月时测量血脂谱和全身免疫炎症指数。在1个月的随访中，与对照组相比，运动组的总胆固醇水平和全身免疫炎症指数评分显著降低（P < 0.005）。在3个月的随访中，运动组的高密度脂蛋白胆固醇（HDL-C）水平显著高于对照组（P < 0.005），低密度脂蛋白胆固醇（LDL-C）和总胆固醇水平低于对照组（P < 0.005）。运动组在3个月时的全身炎症指数（SII）评分也显著降低（P < 0.001）。比目鱼肌俯卧撑运动可能对CAD患者的血脂谱和全身免疫炎症指数产生积极影响，突出了一种管理心血管危险因素的潜在非侵入性方法。
