吸入酸性气溶胶对肺力学的影响：人体暴露研究分析
Effects of inhaled acid aerosols on lung mechanics: an analysis of human exposure studies.
作者信息
Utell M J
出版信息
Environ Health Perspect. 1985 Nov;63:39-44. doi: 10.1289/ehp.856339.
Abstract
There exist significant gaps in our understanding of human health effects from inhalation of pollutants associated with acid precipitation. Controlled clinical studies examine effects of criteria pollutants almost exclusively by assessing changes in lung mechanics. One constituent of acid precipitation, sulfuric acid aerosols, has been shown to induce bronchoconstriction in exercising extrinsic asthmatics at near ambient levels. These asthmatics may be an order of magnitude more sensitive to sulfuric acid aerosols than normal adults. More recently, a second component nitrogen dioxide has been observed to provoke changes in lung mechanics at progressively lower concentrations. To date, virtually no data exist from clinical exposures to acidic aerosols for subjects with chronic obstructive pulmonary disease.
摘要
我们对吸入与酸雨相关污染物对人体健康影响的认识存在重大差距。对照临床研究几乎完全通过评估肺力学变化来研究标准污染物的影响。酸雨的一种成分硫酸气溶胶已被证明在接近环境水平时会诱发运动性外源性哮喘患者的支气管收缩。这些哮喘患者对硫酸气溶胶的敏感性可能比正常成年人高一个数量级。最近，已观察到另一种成分二氧化氮在浓度逐渐降低时会引起肺力学变化。迄今为止，几乎没有关于慢性阻塞性肺疾病患者临床接触酸性气溶胶的数据。
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