Lodi Giuseppe, Cannarozzo Giovanni, Fusco Irene, Zingoni Tiziano, Campione Elena, Sannino Mario
Unit of Dermatology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Lasers in Dermatology Unit, University of Rome Tor Vergata, Rome, Italy.
AME Case Rep. 2025 Jul 9;9:77. doi: 10.21037/acr-24-215. eCollection 2025.
Ulerythema ophryogenes (UO) is a rare cutaneous disorder characterized by inflammatory keratotic papules that primarily affect the face. This clinical case may enrich and provide an interesting literature overview on the laser therapy for UO, which represents a rare skin illness difficult to treat.
A 25-year-old female patient having an UO family history and who presented a progressive erythema and confluent horny follicular erythematous papules with areas of alopecia around the lateral third of eyebrows without signs of pitted or atrophic scars, which has been evident since childhood, underwent to a single session of dye laser. She was complaining of discomfort in the involved skin areas. The patient had not been taking any medications prior to laser therapy. The use of anaesthetic was avoided. After only one therapy session of dye laser the result was clinically optimal. A visible reduction in roughness and a partial hair regrowth in the treated area were observed at 2 months follow-up after treatment. The horn plugs were no longer evident, and the erythema had subsided. The hairs had become thicker, darker, and more numerous, covering most of the underlying dermatitis. Following the laser procedure, the patient didn't experience complications or severe adverse reactions.
Pulsed dye laser treatment appears to be a safe and effective treatment for the erythema and alopecia symptoms associated with this refractory condition.
眉部瘢痕性红斑(UO)是一种罕见的皮肤疾病,其特征为炎性角化丘疹,主要累及面部。该临床病例可能会丰富并提供关于UO激光治疗的有趣文献综述,UO是一种难以治疗的罕见皮肤疾病。
一名25岁女性患者,有UO家族病史,自幼出现渐进性红斑、融合性角质毛囊性红斑丘疹,眉毛外侧三分之一周围有脱发区,无凹陷或萎缩性瘢痕迹象,接受了单次染料激光治疗。她主诉受累皮肤区域不适。激光治疗前患者未服用任何药物,未使用麻醉剂。仅经过一次染料激光治疗,临床效果就达到了最佳。治疗后2个月随访时,观察到治疗区域粗糙度明显降低,部分毛发再生。角栓不再明显,红斑消退。毛发变得更粗、更黑、更多,覆盖了大部分潜在的皮炎区域。激光治疗后,患者未出现并发症或严重不良反应。
脉冲染料激光治疗似乎是治疗这种难治性疾病相关红斑和脱发症状的一种安全有效的方法。