Niazi Bilal, Quach Bill, Fisher Kurt, Peeraphatdit Thoetchai
Department of Gastroenterology and Hepatology, College of Medicine, University of Nebraska Medical Center, Omaha, NE.
Department of Pathology, College of Medicine, University of Nebraska Medical Center, Omaha, NE.
ACG Case Rep J. 2025 Aug 4;12(8):e01803. doi: 10.14309/crj.0000000000001803. eCollection 2025 Aug.
Selective androgen receptor modulators (SARMs) are anabolic compounds that modulate androgen activity. They have been increasingly used in supplements to enhance performance and muscle growth despite not being Food and Drug Administration approved. Their use has been associated with a cholestatic pattern of liver injury similar to that seen by anabolic androgens. Treatment is primarily supportive with drug cessation and cholestasis can take weeks to months to normalize. We present an atypical case of prolonged cholestasis caused by the readily available selective androgen receptor modulator called RAD-140 that was successfully managed with corticosteroids.
选择性雄激素受体调节剂（SARMs）是调节雄激素活性的合成代谢化合物。尽管未获得美国食品药品监督管理局的批准，但它们越来越多地被用于补充剂中以提高运动表现和促进肌肉生长。它们的使用与一种胆汁淤积型肝损伤有关，类似于合成代谢雄激素所致的肝损伤。治疗主要是支持性的，需停用药物，胆汁淤积可能需要数周数月才能恢复正常。我们报告了一例由 readily available（此处有误，应是readily available，意为“容易获得的”）选择性雄激素受体调节剂RAD-140引起的长期胆汁淤积的非典型病例，该病例通过皮质类固醇成功治愈。
