Peng Hui, Zhou Dan, Dai Yuan, Chen Weifeng
General Medicine Department, Shenzhen Second People's Hospital (The First Affiliated of Shenzhen University), Shenzhen, Guangdong, China.
Behav Neurol. 2025 Jul 28;2025:8868665. doi: 10.1155/bn/8868665. eCollection 2025.
Depression is one of the most common diseases in the world. Earlier research on the link between body mass index (BMI) and depression has been contentious. This study seeks to investigate the connection between BMI and depression among individuals with nonalcoholic fatty liver disease (NAFLD). All data were extracted from the National Health and Nutrition Examination Survey (NHANES) database 2017-2018. The Cox regression technique was employed to analyze the link between BMI and depression. To analyze the potential nonlinear connection between BMI and depression, Cox proportional hazards regression incorporating cubic spline functions and smooth curve fitting was utilized. In addition, a two-segment Cox proportional hazards regression model was used to pinpoint the inflection point at which BMI impacts the likelihood of depression. The Patient Health Questionnaire (PHQ-9) was the primary measure of depressive symptoms. The mean age of the 1426 participants was 56.05 years with a standard deviation of 15.63 years, and approximately 49.30% of the sample were male. After controlling for confounding variables, BMI demonstrated a positive association with depression (OR:1.05, 95% CI:1.02-1.09, < 0.004). The two-piecewise Cox proportional hazards regression model identified an inflection point for BMI at 29.8 kg/m. Below this inflection point (BMI ≤ 29.8 kg/m), BMI was positively correlated with an increased risk of depression (OR:1.23, 95% CI:1.04-1.45, < 0.014). Conversely, when BMI exceeded 29.8 kg/m, the association was not statistically significant (OR: 1.02, 95% CI: 0.98-1.07, = 0.305). There is a nonlinear relationship between BMI and depression among patients with NAFLD. BMI was positively related to depression when BMI is less than 29.8 kg/m.
抑郁症是世界上最常见的疾病之一。早期关于体重指数（BMI）与抑郁症之间联系的研究一直存在争议。本研究旨在调查非酒精性脂肪性肝病（NAFLD）患者中BMI与抑郁症之间的关联。所有数据均从2017 - 2018年国家健康与营养检查调查（NHANES）数据库中提取。采用Cox回归技术分析BMI与抑郁症之间的联系。为了分析BMI与抑郁症之间潜在的非线性联系，使用了纳入三次样条函数和光滑曲线拟合的Cox比例风险回归。此外，使用两段式Cox比例风险回归模型来确定BMI影响抑郁症发生可能性的拐点。患者健康问卷（PHQ - 9）是抑郁症状的主要测量指标。1426名参与者的平均年龄为56.05岁，标准差为15.63岁，样本中约49.30%为男性。在控制混杂变量后，BMI与抑郁症呈正相关（OR：1.05，95% CI：1.02 - 1.09，<0.004）。两段式Cox比例风险回归模型确定BMI的拐点为29.8kg/m²。在这个拐点以下（BMI≤29.8kg/m²），BMI与抑郁症风险增加呈正相关（OR：1.23，95% CI：1.04 - 1.45，<0.014）。相反，当BMI超过29.8kg/m²时，这种关联无统计学意义（OR：1.02，95% CI：0.98 - 1.07，=0.305）。NAFLD患者中BMI与抑郁症之间存在非线性关系。当BMI小于29.8kg/m²时，BMI与抑郁症呈正相关。
