Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Department of Nutritional Science and Dietetics, School of Health Science, University of the Peloponnese, Kalamata, Greece.
Front Endocrinol (Lausanne). 2023 Jul 14;14:1197648. doi: 10.3389/fendo.2023.1197648. eCollection 2023.
Obesity is a significant worldwide health problem that is linked with mental health. The elucidation of the possible overlapping biochemical mechanism(s) involved in inflammation and oxidative stress is imperative to better understand and address obesity and related metabolic disorders. The aim of the study was to investigate the associations between inflammatory and oxidative stress profiles with parameters that reflect metabolic, emotional, and mental health in a Greek metabolically unhealthy obese cohort.
In total, 122 metabolically unhealthy people with obesity were recruited. Anthropometric measurements, biochemical, inflammatory and oxidative stress markers were assessed. Quality of life was evaluated through questionnaires for insomnia, self-esteem, depression, physical and mental health.
The inflammatory biomarker tumor necrosis factor-alpha (TNF-α) and the ratio oxidized low-density lipoprotein/low-density lipoprotein (oxLDL/LDL) were higher in hypertensive (p=0.002, p=0.001 respectively) and hyperglycemic subjects (p=0.017, p=0.001 respectively). Furthermore TNF-α (p<0.001), oxLDL/LDL (p<0.001) and oxLDL/high-density lipoprotein (HDL) (p=0.016) increased significantly with the increase of metabolic syndrome components. Finally, a negative association between interleukin-6 (IL-6) and Rosenberg Self-Esteem Scale (Beta=-0.019, p=0.019) and a positive association between TNF-α and the Center for Epidemiologic Studies Depression Scale Revised (Beta=0.003, p=0.015) were found.
The results of the study suggest that obesity-related systemic inflammation is associated with worse self-esteem and depression symptoms, indicating an overlapping mechanism which can be utilized to the management of obesity.
肥胖是一个全球性的健康问题，与心理健康有关。阐明炎症和氧化应激中可能重叠的生化机制对于更好地理解和解决肥胖及相关代谢紊乱至关重要。本研究旨在探讨希腊代谢不健康肥胖人群中炎症和氧化应激指标与代谢、情绪和心理健康参数之间的相关性。
共招募了 122 名代谢不健康的肥胖患者。评估了人体测量学指标、生化、炎症和氧化应激标志物。通过失眠、自尊、抑郁、身体和心理健康问卷评估生活质量。
高血压患者（p=0.002，p=0.001）和高血糖患者（p=0.017，p=0.001）的炎症生物标志物肿瘤坏死因子-α（TNF-α）和氧化型低密度脂蛋白/低密度脂蛋白（oxLDL/LDL）比值较高。此外，TNF-α（p<0.001）、oxLDL/LDL（p<0.001）和 oxLDL/高密度脂蛋白（HDL）（p=0.016）随着代谢综合征成分的增加而显著增加。最后，白细胞介素-6（IL-6）与 Rosenberg 自尊量表（Beta=-0.019，p=0.019）呈负相关，TNF-α与流行病学研究抑郁量表修订版（Beta=0.003，p=0.015）呈正相关。
研究结果表明，肥胖相关的全身炎症与自尊和抑郁症状恶化有关，表明存在重叠的机制，可用于肥胖的管理。
