Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V
Food Chem Toxicol. 1985 Nov;23(11):985-90. doi: 10.1016/0278-6915(85)90248-0.
The influence of dietary xylitol on the quantity and quality of faecal microflora was studied in Wistar albino rats, CD-1 mice and healthy human volunteers. In animals, the effects of xylitol adaptation and of 4-wk xylitol feeding were examined. No major changes in the numbers of total aerobic or anaerobic bacteria, aerobic streptococci, anaerobic streptococci or yeasts were observed, although there was evidence of a dose-dependent decrease in the numbers of aerobic streptococci in the faeces. However, xylitol feeding caused a clear shift in the rodent faecal microbial population from Gram-negative to Gram-positive bacteria. In human volunteers a similar shift was observed even after a single 30-g oral dose of xylitol. All animals were capable of adapting to 20% dietary xylitol and an accompanying enhancement of the ability of caecal and faecal flora to utilize xylitol was observed.
在Wistar白化大鼠、CD-1小鼠和健康人类志愿者中研究了膳食木糖醇对粪便微生物群落数量和质量的影响。在动物实验中，研究了木糖醇适应性以及4周木糖醇喂养的效果。虽然有证据表明粪便中需氧链球菌数量呈剂量依赖性减少，但未观察到总需氧菌或厌氧菌、需氧链球菌、厌氧链球菌或酵母菌数量的重大变化。然而，木糖醇喂养导致啮齿动物粪便微生物群落从革兰氏阴性菌明显转变为革兰氏阳性菌。在人类志愿者中，即使单次口服30克木糖醇后也观察到了类似的转变。所有动物都能够适应20%的膳食木糖醇，并且观察到盲肠和粪便菌群利用木糖醇的能力随之增强。
