Mathur R, Reddy V, Naidu A N, Krishnamachari K A
Hum Nutr Clin Nutr. 1985 Nov;39(6):447-54.
Malnutrition and diarrhoeal diseases are important interrelated health problems of preschool children in the developing countries. For a prospective study to determine the effect of malnutrition on diarrhoeal morbidity 721 children under 5 years, living in two villages near Hyderabad were registered. The children were classified into different nutritional grades based on initial body weights and heights; and diarrhoea morbidity was recorded during the subsequent one year. The aetiology of diarrhoea was determined in a subsample. The incidence of diarrhoea was observed to be about 1.6 episodes/child/year and was similar in children with different nutritional grades. The percentage of episodes leading to severe dehydration was, however, significantly higher (P less than 0.05) in children with grade III malnutrition. The isolation of ETEC was also higher in this group indicating a greater bacterial load in the gut. Although pre-existing malnutrition did not affect the incidence of diarrhoea it seems to have a significant impact on the severity of the disease.
营养不良和腹泻病是发展中国家学龄前儿童面临的重要且相互关联的健康问题。为了进行一项前瞻性研究以确定营养不良对腹泻发病率的影响，对居住在海得拉巴附近两个村庄的721名5岁以下儿童进行了登记。根据初始体重和身高将儿童分为不同的营养等级；并在随后的一年中记录腹泻发病率。在一个子样本中确定了腹泻的病因。观察到腹泻发病率约为1.6次/儿童/年，不同营养等级的儿童发病率相似。然而，III度营养不良儿童中导致严重脱水的腹泻发作百分比显著更高（P小于0.05）。该组中肠毒素大肠杆菌的分离率也更高，表明肠道中的细菌负荷更大。虽然先前存在的营养不良不影响腹泻发病率，但似乎对疾病的严重程度有显著影响。
