钍造影剂和可的松对家兔肾皮质纤溶活性的影响。
The effect of thorotrast and cortisone on renal cortical fibrinolytic activity in the rabbit.
作者信息
Bergstein J M, Michael A F
出版信息
Am J Pathol. 1973 Apr;71(1):113-8.
Previous studies have shown that a single injection of endotoxin inhibits renal cortical fibrinolytic activity in the rabbit. This suggests that the initial injection of endotoxin may prepare for the generalized Shwartzman reaction by depletion of cortical fibrinolytic activity. A fibrin slide technic was used to determine whether Thorotrast(R) and cortisone prepare for the generalized Schwartzman reaction by a similar mechanism. Renal cortical fibrinolytic activity was inhibited following Thorotrast injection, but no inhibition could be detected following cortisone injection. This suggests that Thorotrast, like endotoxin, prepares for the generalized Shwartzman reaction by depletion of cortical fibrinolytic activity. Failure to demonstrate inhibition of lytic activity following cortisone injection may indicate that cortisone prepares for the generalized Shwartzman reaction by another mechanism, or that the fibrin slide technic was unable to detect quantitative changes in lytic activity.
以往的研究表明，单次注射内毒素可抑制家兔肾皮质的纤溶活性。这表明，最初注射内毒素可能通过消耗皮质纤溶活性为全身性施瓦茨曼反应做准备。采用纤维蛋白玻片技术来确定钍造影剂（Thorotrast）和可的松是否通过类似机制为全身性施瓦茨曼反应做准备。注射钍造影剂后肾皮质纤溶活性受到抑制，但注射可的松后未检测到抑制作用。这表明钍造影剂与内毒素一样，通过消耗皮质纤溶活性为全身性施瓦茨曼反应做准备。注射可的松后未能证明其对溶解活性的抑制作用，可能表明可的松通过另一种机制为全身性施瓦茨曼反应做准备，或者纤维蛋白玻片技术无法检测到溶解活性的定量变化。
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