对羟基苄青霉素（青霉素X）及其他五种青霉素对淋病奈瑟菌的体外活性：来自无并发症感染患者及盆腔炎女性患者菌株的比较
In vitro activity of p-hydroxybenzyl penicillin (penicillin X) and five other penicillins against Neisseria gonorrhoeae: comparisons of strains from patients with uncomplicated infections and from women with pelvic inflammatory disease.
作者信息
Sackel S G, Alpert S, Rosner B, McCormack W M, Finland M
出版信息
Antimicrob Agents Chemother. 1977 Jul;12(1):31-6. doi: 10.1128/AAC.12.1.31.
Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strains, the order of activity observed was: BL-P1654 > penicillin X > penicillin G > ampicillin > amoxicillin = carbenicillin. MICs against strains isolated from women with gonococcal pelvic inflammatory disease were significantly higher than those against isolates from uncomplicated infections: BL-P1654, P < 0.001; penicillin X, P < 0.001; penicillin G, P < 0.001; ampicillin, P < 0.001; and amoxicillin, P < 0.05. MICs of penicillin G were >/=0.125 mug/ml against 33 (36%) of the 92 strains from patients with uncomplicated infections, as contrasted with 15 (68%) of the 22 isolates from women with pelvic inflammatory disease (P < 0.01). The means of the MICs of penicillin G were 0.06 mug/ml for the former and 0.14 mug/ml for the latter.
采用接种复制器，通过琼脂平板稀释法测定了六种青霉素对95株无并发症肛门生殖器感染患者的淋病奈瑟菌以及22株盆腔炎女性患者的淋病奈瑟菌的最低抑菌浓度（MICs）。对于所有117株菌株，观察到的活性顺序为：BL-P1654 > 青霉素X > 青霉素G > 氨苄西林 > 阿莫西林 = 羧苄西林。从患有淋菌性盆腔炎的女性中分离出的菌株的MICs显著高于无并发症感染分离株的MICs：BL-P1654，P < 0.001；青霉素X，P < 0.001；青霉素G，P < 0.001；氨苄西林，P < 0.001；阿莫西林，P < 0.05。青霉素G对92株无并发症感染患者菌株中的33株（36%）的MICs≥0.125μg/ml，相比之下，22株盆腔炎女性分离株中有15株（68%）（P < 0.01）。青霉素G的MICs平均值，前者为0.06μg/ml，后者为0.14μg/ml。
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