Bennekou Suzanne Hougaard, Allende Ana, Bearth Angela, Casacuberta Josep, Castle Laurence, Coja Tamara, Crépet Amélie, Halldorsson Thorhallur, Hoogenboom Laurentius Ron, Knutsen Helle, Lambré Claude, Nielsen Søren, Turck Dominique, Civera Antonio Vicent, Villa Roberto, Jokelainen Pikka, Zorn Holger, Benford Diane, Fitzgerald Rex, Meek Bette, Mortensen Alicja, Sand Salomon, Testai Emanuela, Manini Paola, Paini Alicia, Schrenk Dieter
EFSA J. 2025 Aug 8;23(8):e9606. doi: 10.2903/j.efsa.2025.9606. eCollection 2025 Aug.
The margin of exposure (MOE) is a risk assessment tool used to evaluate the safety of substances in food and feed. Adopted by the European Food Safety Authority (EFSA) in 2005, the MOE is calculated as the ratio between a Reference Point (RP) and the estimated exposure. While some regulatory bodies use 'margin of safety' (MOS) interchangeably with MOE, others define it differently, leading to inconsistencies in interpretation. To address this, EFSA has standardised its terminology, establishing MOE as a primary metric for safety assessments across human and animal health evaluations. In addition, the meaning and interpretation of terms used to qualify a 'concern' is elaborated. The EFSA definitions will come into force from when this statement is published. By refining these definitions and ensuring consistent terminology across sectors, EFSA aims to improve clarity and transparency in its risk assessments, facilitating effective communication.
暴露边际（MOE）是一种用于评估食品和饲料中物质安全性的风险评估工具。欧洲食品安全局（EFSA）于2005年采用了MOE，它被计算为参考点（RP）与估计暴露量之间的比率。虽然一些监管机构将“安全边际”（MOS）与MOE互换使用，但其他机构对其定义不同，导致解释上的不一致。为了解决这个问题，EFSA对其术语进行了标准化，将MOE确立为人类和动物健康评估中安全评估的主要指标。此外，还阐述了用于限定“关注”的术语的含义和解释。EFSA的定义将自本声明发布之日起生效。通过完善这些定义并确保各部门术语的一致性，EFSA旨在提高其风险评估的清晰度和透明度，促进有效沟通。
