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科学评估中的不确定性分析指南。

Guidance on Uncertainty Analysis in Scientific Assessments.

作者信息

Benford Diane, Halldorsson Thorhallur, Jeger Michael John, Knutsen Helle Katrine, More Simon, Naegeli Hanspeter, Noteborn Hubert, Ockleford Colin, Ricci Antonia, Rychen Guido, Schlatter Josef R, Silano Vittorio, Solecki Roland, Turck Dominique, Younes Maged, Craig Peter, Hart Andrew, Von Goetz Natalie, Koutsoumanis Kostas, Mortensen Alicja, Ossendorp Bernadette, Martino Laura, Merten Caroline, Mosbach-Schulz Olaf, Hardy Anthony

出版信息

EFSA J. 2018 Jan 24;16(1):e05123. doi: 10.2903/j.efsa.2018.5123. eCollection 2018 Jan.

DOI:10.2903/j.efsa.2018.5123
PMID:32625671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7009727/
Abstract

Uncertainty analysis is the process of identifying limitations in scientific knowledge and evaluating their implications for scientific conclusions. It is therefore relevant in all EFSA's scientific assessments and also necessary, to ensure that the assessment conclusions provide reliable information for decision-making. The form and extent of uncertainty analysis, and how the conclusions should be reported, vary widely depending on the nature and context of each assessment and the degree of uncertainty that is present. This document provides concise guidance on how to identify which options for uncertainty analysis are appropriate in each assessment, and how to apply them. It is accompanied by a separate, supporting opinion that explains the key concepts and principles behind this Guidance, and describes the methods in more detail.

摘要

不确定性分析是识别科学知识中的局限性并评估其对科学结论影响的过程。因此,它在欧洲食品安全局(EFSA)的所有科学评估中都具有相关性,并且对于确保评估结论为决策提供可靠信息也是必要的。不确定性分析的形式和程度,以及结论应如何报告,会因每项评估的性质和背景以及存在的不确定性程度而有很大差异。本文件就如何确定在每项评估中哪些不确定性分析选项合适以及如何应用这些选项提供了简明指导。同时还附有一份单独的支持性意见,解释了本指南背后的关键概念和原则,并更详细地描述了方法。

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本文引用的文献

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EFSA J. 2018 Jan 24;16(1):e05122. doi: 10.2903/j.efsa.2018.5122. eCollection 2018 Jan.
2
Guidance on the use of the weight of evidence approach in scientific assessments.科学评估中证据权重方法的使用指南。
EFSA J. 2017 Aug 3;15(8):e04971. doi: 10.2903/j.efsa.2017.4971. eCollection 2017 Aug.
应用于动物的生物技术新进展:对欧洲食品安全局当前动物风险评估指南的充分性和完整性的评估。
EFSA J. 2025 Aug 4;23(8):e9566. doi: 10.2903/j.efsa.2025.9566. eCollection 2025 Aug.
4
Welfare of American mink, red and Arctic foxes, raccoon dog and chinchilla kept for fur production.用于毛皮生产的美国水貂、赤狐和北极狐、貉及毛丝鼠的福利。
EFSA J. 2025 Jul 30;23(7):e9519. doi: 10.2903/j.efsa.2025.9519. eCollection 2025 Jul.
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Guidance on the use of read-across for chemical safety assessment in food and feed.食品和饲料中化学品安全评估的类推法使用指南。
EFSA J. 2025 Jul 28;23(7):e9586. doi: 10.2903/j.efsa.2025.9586. eCollection 2025 Jul.
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EFSA J. 2025 Jul 25;23(7):e9518. doi: 10.2903/j.efsa.2025.9518. eCollection 2025 Jul.
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Updated consumer risk assessment of fluoride in food and drinking water including the contribution from other sources of oral exposure.食品和饮用水中氟化物的更新版消费者风险评估,包括其他口腔暴露来源的贡献。
EFSA J. 2025 Jul 22;23(7):e9478. doi: 10.2903/j.efsa.2025.9478. eCollection 2025 Jul.
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Consumption of Ultraprocessed Foods Among Brazilian Pregnant Women Attended in Primary Healthcare.巴西初级医疗保健机构中孕妇的超加工食品消费情况。
J Nutr Metab. 2025 Jun 2;2025:4538910. doi: 10.1155/jnme/4538910. eCollection 2025.
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