Asgarirad Hossein, Mahjoub Soleiman, Yadollahi Mohsen, Navaee Siamak, Amirkhanloo Shervin, Shohreh AliSina
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2025 May 15;16(3):417-423. doi: 10.22088/cjim.16.3.417. eCollection 2025 Summer.
Type 2 diabetes or non-insulin-dependent diabetes is one of the most common types of diabetes. The existing treatments for type 2 diabetes have not been able to completely cure this disease in affected cases. Sumac showed antioxidants, reducing blood sugar and serum cholesterol levels. In this study, according to the positive effects of sumac in diabetic diseases, it was tried that sumac capsules were prepared from the aqueous extract of this plant, and its effect on the factors of diabetes in patients was evaluated.
This double-blind randomized controlled clinical trial was conducted on sixty type 2diabetic volunteers. The volunteers were divided into two groups, control, and sumac supplement groups. Baseline venous blood samples were collected after overnight fasting before intervention and a second sampling was done in the 12th week. Hb1AC, FBS, TG, TC, LDL-C, and HDL-C were measured via commercial kits.
FBS, HDL-C, and HbA1C measured in the sumac supplement group were significantly different (p<0.01) compared to the control group and baseline of the study. Moreover, there is no significant difference in levels of the sumac supplement group (CHOL, LDL-C, and TG) compared to the control group and baseline of the study (p>0.05).
Our data confirmed the anti-diabetic effect of sumac in patients. Because of sumac safety, it seems that sumac capsules can be used for the treatment of diabetic patients along with routine chemical drugs.
2型糖尿病或非胰岛素依赖型糖尿病是最常见的糖尿病类型之一。现有的2型糖尿病治疗方法在受影响的病例中未能完全治愈这种疾病。漆树显示出抗氧化作用，可降低血糖和血清胆固醇水平。在本研究中，根据漆树在糖尿病疾病中的积极作用，尝试从该植物的水提取物制备漆树胶囊，并评估其对患者糖尿病相关因素的影响。
这项双盲随机对照临床试验针对60名2型糖尿病志愿者进行。志愿者被分为两组，即对照组和漆树补充剂组。在干预前空腹过夜后采集基线静脉血样本，并在第12周进行第二次采样。通过商业试剂盒测量Hb1AC、空腹血糖（FBS）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。
与对照组和研究基线相比，漆树补充剂组测量的空腹血糖、高密度脂蛋白胆固醇和糖化血红蛋白（HbA1C）有显著差异（p<0.01）。此外，与对照组和研究基线相比，漆树补充剂组的胆固醇、低密度脂蛋白胆固醇和甘油三酯水平无显著差异（p>0.05）。
我们的数据证实了漆树对患者的抗糖尿病作用。由于漆树的安全性，漆树胶囊似乎可以与常规化学药物一起用于治疗糖尿病患者。
