Zaky Zaky A, Hennache Ali, Zhaketov V D
Physics Department, Faculty of Sciences, Beni-Suef University, Beni Suef, 62514, Egypt.
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russia.
Sci Rep. 2025 Aug 11;15(1):29424. doi: 10.1038/s41598-025-14176-9.
This study presents the design and theoretical analysis of a pseudo parity-time symmetric photonic crystal biosensor for early oral cancer detection. Using the transfer matrix method, we numerically investigated the resonant transmission properties of a 1D photonic crystal structure with a central defect layer (D = 50 μm) containing healthy and cancer oral cells. The proposed [Formula: see text] configuration exhibits exceptional sensitivity, quantified by two key metrics: a spectral sensitivity of 118 GHz/RIU and an extraordinary transmittance sensitivity of [Formula: see text] These results demonstrate significant improvements over conventional photonic biosensors, enabled by the PT-symmetric design's ability to operate near an exceptional point. The optimized structure achieves ultra-sharp resonances ([Formula: see text] THz FWHM) with remarkable field enhancement, making it particularly suitable for detecting minute refractive index changes associated with malignant transformations. Our findings establish a foundation for developing high-performance, label-free diagnostic tools for early-stage oral cancer detection.
本研究展示了一种用于早期口腔癌检测的伪宇称-时间对称光子晶体生物传感器的设计及理论分析。利用传输矩阵法，我们对具有包含健康和癌性口腔细胞的中心缺陷层（D = 50μm）的一维光子晶体结构的共振传输特性进行了数值研究。所提出的[公式：见正文]结构表现出卓越的灵敏度，由两个关键指标量化：光谱灵敏度为118 GHz/RIU，以及非凡的透过率灵敏度为[公式：见正文]。这些结果表明，与传统光子生物传感器相比有显著改进，这得益于宇称-时间对称设计在异常点附近运行的能力。优化后的结构实现了超尖锐共振（[公式：见正文]太赫兹半高宽）以及显著的场增强，使其特别适合检测与恶性转化相关的微小折射率变化。我们的研究结果为开发用于早期口腔癌检测的高性能、无标记诊断工具奠定了基础。
