Evensmoen Hallvard Røe, Rimol Lars M, Rise Henning Stople, Hansen Tor Ivar, Nili Hamed, Winkler Anderson M, Håberg Asta
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
MiDT National Research Center, Center for Innovation, Medical Equipment, and Technology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Imaging Neurosci (Camb). 2025 Jan 9;3. doi: 10.1162/imag_a_00433. eCollection 2025.
The role of precise timing in episodic memory remains obscure. We showed 139 participants episodes consisting of objects, and tested subsequent memory for the precise timing and order of the objects and episodes. Temporal compression of the episode enhanced memory for relative but not absolute timing of the objects' presentation and their order. Conversely, temporal expansion between neighboring episodes was associated with successful memory for episode order. fMRI in 36 participants revealed that temporal compression of the episode was associated with more similar activation patterns within episodes in several brain regions including the posterior hippocampus. However, the activation pattern in the anterior hippocampus and other brain regions became more unique with temporal expansion between neighboring episodes. We propose that human episodic memory relies on two fundamentally opposite processes: pattern integration helps strengthen the relationship between the items that make up an episode and pattern differentiation keeps different episodes apart.
精确计时在情景记忆中的作用仍不清楚。我们向139名参与者展示了由物体组成的情景，并测试了他们随后对物体以及情景的精确计时和顺序的记忆。情景的时间压缩增强了对物体呈现的相对而非绝对计时及其顺序的记忆。相反，相邻情景之间的时间扩展与情景顺序的成功记忆相关。对36名参与者进行的功能磁共振成像显示，情景的时间压缩与包括后海马体在内的几个脑区中情景内更相似的激活模式相关。然而，随着相邻情景之间的时间扩展，前海马体和其他脑区的激活模式变得更加独特。我们提出，人类情景记忆依赖于两个根本相反的过程：模式整合有助于加强构成一个情景的项目之间的关系，而模式分化则使不同情景保持分开。
