基于CRISPR-Cas核酸酶、碱基编辑器和引导编辑器的基因组编辑育种
Genome Editing Breeding with CRISPR-Cas Nucleases, Base Editors, and Prime Editors.
作者信息
Li Guo, Zhou Xinzhi, Zhu Guanglin, Pan Yingjia, Yan Junjun, Meng Jilun, Ye Tiantian, Cheng Yaxian, Liu Cui, Gu Zhimin
机构信息
Xianghu Laboratory, Hangzhou 311231, China.
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
出版信息
Animals (Basel). 2025 Jul 22;15(15):2161. doi: 10.3390/ani15152161.
This review focuses on CRISPR genome editing technology, particularly its application in the study of (). It first elaborates on the basic principles and mechanisms of CRISPR-Cas9 technology, base editors, and prime editors. Then, it explores the application of this technology in breeding, including improving growth rate, enhancing disease resistance, and sex control. Additionally, it introduces the progress of genome editing technology in , epidemiology and pathogenesis, diagnostic techniques, analyzes the opportunities and challenges it faces, reviews the historical evolution, and looks ahead to future development directions. CRISPR technology has brought new opportunities to the research and industrial development of , but it also needs to address numerous technical and safety challenges.
本综述聚焦于CRISPR基因组编辑技术，尤其是其在（）研究中的应用。它首先阐述了CRISPR-Cas9技术、碱基编辑器和引导编辑器的基本原理及机制。然后，探讨了该技术在（）育种中的应用，包括提高生长速度、增强抗病性和性别控制。此外，介绍了基因组编辑技术在（）、流行病学和发病机制、诊断技术方面的进展，分析了其面临的机遇与挑战，回顾了历史沿革，并展望了未来的发展方向。CRISPR技术给（）的研究和产业发展带来了新机遇，但也需要应对众多技术和安全挑战。
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