Nunes Rayanne A, Dias Kelly M M, Duarte Marcio S, Brito Claudson O, Nunes Ricardo V, Petrolli Tiago G, Borges Samuel O, Castro Larissa P, Vale Beatriz G, Calderano Arele A
Department of Animal Science, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil.
Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Animals (Basel). 2025 Jul 26;15(15):2203. doi: 10.3390/ani15152203.
This study investigated the effects of dietary capsaicinoid (CAP) supplementation on broiler chickens subjected to an inflammatory challenge induced by lipopolysaccharide (LPS). A total of 144 Cobb500™ male broilers (Rivelli Alimentos SA, Matheus Leme, Brazil), raised from 1 to 21 days, were randomly assigned to three treatments, with eight replicates of six birds. Treatments were a control diet (CON), a control diet with LPS administration (CON+LPS), and a control diet supplemented with 1 mg CAP/kg feed and LPS (CAP+LPS). LPS was administered intraperitoneally on days 14, 16, 18, and 20. Performance, intestinal morphometry, serum metabolites, and jejunal gene expression related to oxidative and inflammatory responses were evaluated. Slaughter was at 20 days. Data were subjected to ANOVA and means compared by Tukey's test at 0.05 significance. CON broilers exhibited the highest feed intake and a better feed conversion ratio ( < 0.05) compared to CON+LPS. CAP+LPS broilers showed higher body weight gain than CON+LPS but lower than CON broilers ( < 0.001). CON+LPS broilers had the highest crypt depth ( = 0.002). Higher mRNA expression of superoxide dismutase and catalase ( > 0.05) was observed in CON broilers. In conclusion, supplementation with a 1 mg CAP/kg diet improves the growth performance and intestinal morphometry of LPS-challenged broiler chickens.
本研究调查了日粮补充辣椒素（CAP）对遭受脂多糖（LPS）诱导的炎症应激的肉鸡的影响。总共144只1至21日龄的科宝500™ 雄性肉鸡（巴西马塞乌斯莱梅里维利食品公司）被随机分为三种处理组，每组六个重复，每个重复六只鸡。处理组分别为对照日粮（CON）、给予LPS的对照日粮（CON+LPS）以及添加1 mg CAP/kg饲料并给予LPS的对照日粮（CAP+LPS）。在第14、16、18和20天腹腔注射LPS。评估了生长性能、肠道形态学、血清代谢物以及与氧化和炎症反应相关的空肠基因表达。20日龄时进行屠宰。数据进行方差分析，均值采用Tukey检验进行比较，显著性水平为0.05。与CON+LPS相比CON肉鸡表现出最高的采食量和更好的饲料转化率（P<0.05）。CAP+LPS肉鸡的体重增加高于CON+LPS组，但低于CON肉鸡（P<0.001）。CON+LPS肉鸡的隐窝深度最高（P = 0.002）。CON肉鸡中超氧化物歧化酶和过氧化氢酶的mRNA表达较高（P>0.05）。总之，日粮中添加1 mg CAP/kg可改善LPS应激肉鸡的生长性能和肠道形态。
