Silveira Vitória, Braz Pamela, Grande Antonio Jose, Colonetti Tamy, Rodrigues Uggioni Maria Laura, da Silveira Prestes Gabriele, Roever Leonardo, Santina Dagostin Valdemira, da Rosa Maria Inês
School of Medicine, Universidade do Extremo Sul Catarinense (UNESC), Criciúma 88806-000, SC, Brazil.
School of Medicine, Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande 79804-970, MS, Brazil.
J Clin Med. 2025 Aug 3;14(15):5458. doi: 10.3390/jcm14155458.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder frequently associated with metabolic and inflammatory disturbances. Due to its antioxidant and anti-inflammatory properties, pomegranate juice has been proposed as a potential adjunctive therapy in managing PCOS. To evaluate the effects of pomegranate juice on hormonal, inflammatory, and lipid parameters and body mass index (BMI) in women with PCOS. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following PRISMA guidelines. Comprehensive searches were performed in electronic databases including Medline, Scopus, Web of Science, Cochrane CENTRAL, and Embase from inception to July 2025, using keywords and MeSH terms related to "polycystic ovary syndrome" and "pomegranate juice" without language restrictions. The primary outcomes were changes in serum testosterone, luteinizing hormone (LH), high-sensitivity C-reactive protein (hs-CRP), lipid profile parameters (HDL, LDL, triglycerides, and total cholesterol), and body mass index (BMI). Four RCTs published between 2020 and 2023, encompassing 128 women with PCOS, were included. The meta-analysis revealed significant reductions in testosterone (MD: -0.05; 95% CI: -0.07 to -0.03; < 0.0001; I = 0%, two studies, 85 participants) and hs-CRP (SMD: -0.85; 95% CI: -1.35 to -0.35; = 0.0009; I = 20%, two studies, 85 participants), along with increases in HDL (MD: 6.21; 95% CI: 2.43 to 10.00; = 0.001; I = 0%, two studies, 85 participants) and reductions in triglycerides (MD: -23.30; 95% CI: -45.19 to -1.42; = 0.04; I = 0%, two studies, 85 participants). No significant changes were observed in LH, LDL, total cholesterol, or BMI. Pomegranate juice demonstrates promising effects as an adjunctive intervention in women with PCOS, improving androgen levels, inflammatory markers, and certain lipid parameters. Further long-term studies are needed to confirm these findings.
多囊卵巢综合征（PCOS）是一种多因素内分泌紊乱疾病，常与代谢和炎症紊乱相关。由于石榴汁具有抗氧化和抗炎特性，已被提议作为管理PCOS的一种潜在辅助治疗方法。为了评估石榴汁对PCOS女性激素、炎症和脂质参数以及体重指数（BMI）的影响。按照PRISMA指南对随机对照试验（RCT）进行了系统评价和荟萃分析。从数据库建立到2025年7月，在包括Medline、Scopus、科学网、Cochrane CENTRAL和Embase在内的电子数据库中进行了全面检索，使用了与“多囊卵巢综合征”和“石榴汁”相关的关键词和医学主题词，无语言限制。主要结局是血清睾酮、促黄体生成素（LH）、高敏C反应蛋白（hs-CRP）、脂质谱参数（高密度脂蛋白、低密度脂蛋白、甘油三酯和总胆固醇）以及体重指数（BMI）的变化。纳入了2020年至2023年发表的4项RCT，涉及128名PCOS女性。荟萃分析显示，睾酮（MD：-0.05；95%CI：-0.07至-0.03；P<0.0001；I² = 0%，两项研究，85名参与者）和hs-CRP（SMD：-0.85；95%CI：-1.35至-0.35；P = 0.0009；I² = 20%，两项研究，85名参与者）显著降低，同时高密度脂蛋白升高（MD：6.21；95%CI：2.43至10.0；P = 0.001；I² = 0%，两项研究，85名参与者），甘油三酯降低（MD：-23.30；95%CI：-45.19至-1.42；P = 0.04；I² = 0%，两项研究，85名参与者）。LH、低密度脂蛋白、总胆固醇或BMI未观察到显著变化。石榴汁作为PCOS女性的辅助干预措施显示出有前景的效果，可改善雄激素水平、炎症标志物和某些脂质参数。需要进一步的长期研究来证实这些发现。
