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石榴皮添加面包对2型糖尿病患者人体测量、代谢和氧化参数的影响:一项双盲、随机、安慰剂对照研究。

The effects of pomegranate peel added bread on anthropometric measurements, metabolic and oxidative parameters in individuals with type 2 diabetes: a double-blind, randomized, placebo-controlled study.

作者信息

Özpak Akkuş Özlem, Metin Uğurcan, Çamlık Zeynep

机构信息

Department of Nutrition and Dietetics, Toros University, Mersin 33140, Turkey.

Department of Culinary, Toros University, Mersin 33140, Turkey.

出版信息

Nutr Res Pract. 2023 Aug;17(4):698-716. doi: 10.4162/nrp.2023.17.4.698. Epub 2023 Feb 24.

Abstract

BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the sensory properties of antioxidant-rich bread made by adding pomegranate peels and their effects on anthropometric measurements and metabolic and oxidative parameters of individuals with type 2 diabetes after consumption.

SUBJECTS/METHODS: This randomized, double-blind, placebo-controlled study was conducted with 22 individuals aged between 19 and 64 years who had been diagnosed with type 2 diabetes for at least 5 years, used only metformin, did not lose more than 10% of their body weight in the last 6 months, and had a body mass index of ≥ 25.0 kg/m. While the study group (n = 11) consumed bread containing 500 mg pomegranate peel daily for 8 wk, the control group (n = 11) consumed standard bread. Anthropometric measurements and metabolic and oxidative parameters of individuals were evaluated at the beginning and end of the study.

RESULTS

Decreases were detected in the waist circumference, waist/hip and waist/height ratios, body fat percentages, blood pressure, and serum insulin, triglyceride, and total cholesterol levels in the individuals in the treatment group, compared with those in the control group ( < 0.05).

CONCLUSIONS

Pomegranate peel consumption by individuals with type 2 diabetes may have positive effects on anthropometric measurements and glycemic and lipid parameters.

摘要

背景/目的:本研究旨在评估添加石榴皮制成的富含抗氧化剂面包的感官特性,以及食用后对2型糖尿病患者人体测量指标、代谢和氧化参数的影响。

受试者/方法:本随机、双盲、安慰剂对照研究纳入了22名年龄在19至64岁之间的个体,他们被诊断为2型糖尿病至少5年,仅使用二甲双胍治疗,在过去6个月内体重减轻不超过10%,且体重指数≥25.0kg/m²。研究组(n = 11)连续8周每天食用含有500毫克石榴皮的面包,对照组(n = 11)食用标准面包。在研究开始和结束时评估个体的人体测量指标、代谢和氧化参数。

结果

与对照组相比,治疗组个体的腰围、腰臀比、腰高比、体脂百分比、血压以及血清胰岛素、甘油三酯和总胆固醇水平均有所下降(P < 0.05)。

结论

2型糖尿病患者食用石榴皮可能对人体测量指标以及血糖和血脂参数产生积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/10375327/b6c5aa6caf46/nrp-17-698-g001.jpg

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