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英国食源性肉毒中毒回顾:2006 - 2024年

Review of Foodborne Botulism in the UK: 2006-2024.

作者信息

Amar Corinne Francoise Laurence, Ahmed Burhan, Finch Jonathan, Rajendram Dunstan, Wong Vanessa K, Godbole Gauri

机构信息

Gastrointestinal Bacteria Reference Unit, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.

Gastrointestinal Infections, Food Safety and One Health, UK Health Security Agency, London NW9 5EQ, UK.

出版信息

Foods. 2025 Jul 23;14(15):2584. doi: 10.3390/foods14152584.

Abstract

Food-borne botulism is a rare but serious disease caused by ingestion of botulinum neurotoxin pre-formed in food by Between 2006 and 2009, no foodborne botulism cases were reported in the UK. However, the period from 2010 to 2024 saw 13 cases, encompassing seven separate incidents and two outbreaks, with no reported fatalities. Cases were predominantly linked to imported, home-made, and artisanal foods, occasionally to commercial products. Diagnostic and public health challenges include delayed clinical diagnosis, delayed sample collection, inadequate specimen volumes, and the frequent unavailability of suspected food sources, hampering epidemiological investigations. The UK has an extremely low incidence of foodborne botulism with an estimated rate of 0.001 cases per 100,000 people per year, but despite this low occurrence, food botulism remains a public health emergency as it requires timely treatment and rapid reactive intervention to be undertaken by multiple regulatory agencies. Continuous professional training of medical staff, up-to-date clinical guidance, rapid diagnostic, and food investigations are essential for optimising patient outcomes and prevention.

摘要

食源性肉毒中毒是一种罕见但严重的疾病,由摄入食物中预先形成的肉毒杆菌神经毒素引起。2006年至2009年期间,英国未报告食源性肉毒中毒病例。然而,2010年至2024年期间出现了13例病例,涉及7起单独事件和2次疫情,无死亡报告。病例主要与进口食品、自制食品和手工制作食品有关,偶尔也与商业产品有关。诊断和公共卫生方面的挑战包括临床诊断延迟、样本采集延迟、样本量不足以及疑似食物来源经常无法获取,这阻碍了流行病学调查。英国食源性肉毒中毒的发病率极低,估计每年每10万人中有0.001例,但尽管发病率很低,食物肉毒中毒仍然是公共卫生紧急事件,因为它需要多个监管机构及时治疗并迅速采取应对干预措施。对医务人员进行持续专业培训、提供最新的临床指导、快速诊断和食品调查对于优化患者治疗效果和预防工作至关重要。

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