Rucci L, Borghi Cirri M B, Masini E, Fini Storchi O
Rhinology. 1985 Dec;23(4):309-14.
The effects of Vidian nerve resection on the histamine content, number and rate of degranulation processes of mast cells in the respiratory tract of the nasal mucosa in patients with intractable chronic hypertrophic non-allergic rhinitis (CHNAR) have been investigated at various times after surgery. Preliminary data are also presented on the effects of Vidian nerve stimulation on the same parameters. The Vidian nerve was stimulated during surgery before resection. After neurotomy the histamine content was significantly lower than before but the values became less low with the passing of time. The number of mast cells per microscopic field and their degranulation index were significantly lower after surgery than before it. Stimulation determines a significant reduction in the number of mast cells per microscopic field and a parallel reduction in histamine content. These data establish a relationship between cholinergic activity and secretory response of mast cells and demonstrate a role of the parasympathetic nerve supply in the pathogenesis of CHNAR. The great reduction in the number of mast cells and histamine content also suggests that the parasympathetic nerve supply could play a role in the regulation of histamine synthesis and uptake.
在难治性慢性肥厚性非过敏性鼻炎（CHNAR）患者中，研究了翼管神经切除术后不同时间对鼻黏膜呼吸道肥大细胞组胺含量、数量及脱颗粒过程发生率的影响。还给出了翼管神经刺激对相同参数影响的初步数据。在切除术前手术过程中对翼管神经进行刺激。神经切断术后组胺含量显著低于术前，但随着时间推移，该值降低程度变小。术后每个显微镜视野下肥大细胞数量及其脱颗粒指数显著低于术前。刺激导致每个显微镜视野下肥大细胞数量显著减少，同时组胺含量平行降低。这些数据确立了胆碱能活性与肥大细胞分泌反应之间的关系，并证明了副交感神经支配在CHNAR发病机制中的作用。肥大细胞数量和组胺含量的大幅降低还表明，副交感神经支配可能在组胺合成和摄取的调节中起作用。
