Rucci L, Masini E, Cirri Borghi M B, Giannella E, Mannaioni P F
Department of Preclinical and Clinical Pharmacology M. Aiazzi-Mancini, Florence University, Italy.
Agents Actions. 1988 Dec;25(3-4):314-20. doi: 10.1007/BF01965037.
The vidian nerve provides the main parasympathetic nerve supply to nasal respiratory and maxillary sinus mucosa, and its electrical stimulation causes apparent secretory and vasodilatatory effects in animals. The present investigation was carried out in 8 patients with chronic hypertrophic non-allergic rhinitis (C.H.N.A.R.) undergoing therapeutic vidian nerve resection. The vidian nerve was electrically stimulated before the resection. Samples were taken from nasal sinus mucosa for histamine determination and microscopical observation before and after the stimulation period. Vidian nerve stimulation causes a significant decrease in histamine content and mast cell density in the mucosa sample, differentially influenced by eserine and atropine pretreatment.
翼管神经为鼻呼吸和上颌窦黏膜提供主要的副交感神经支配，对动物进行翼管神经电刺激会产生明显的分泌和血管舒张效应。本研究对8例接受翼管神经治疗性切除术的慢性肥厚性非过敏性鼻炎（C.H.N.A.R.）患者进行。在切除术前对翼管神经进行电刺激。在刺激期前后，从鼻窦黏膜取样进行组胺测定和显微镜观察。翼管神经刺激导致黏膜样本中组胺含量和肥大细胞密度显著降低，毒扁豆碱和阿托品预处理对其有不同影响。
