Rucci L, Masini E, Arbi Riccardi R, Giannella E, Fioretti C, Mannaioni P F, Borghi Cirri M B, Fini Storchi O
Department of Otorhinolaryngology, University of Florence, Italy.
Agents Actions. 1989 Nov;28(3-4):224-30. doi: 10.1007/BF01967406.
Parasympathetic innervation of the respiratory tract of nasal mucosa plays an important role in the pathogenesis of chronic hypertrophic non-allergic rhinitis (C.H.N.A.R.), the vidian nerve providing the main parasympathetic nerve supply to respiratory mucosa. The present study investigates the effect of vidian nerve resection in 22 patient with intractable C.H.N.A.R. on histamine content and formation and on the number of mast cells and their degranulation in the respiratory tract. Samples were taken from respiratory mucosa for histamine and histidine-decarboxylase assay, and for microscopic observations for mast cell density and degranulation index, before and 12-24 months after vidian nerve resection. Neurectomy of the vidian nerve completely cured the clinical symptomatology, evaluated by rhinoreomanometry, and also significantly decreased both the high histamine levels and histidine-decarboxylase activity in patients with C.H.N.A.R. The density and degranulation index of mast cells were also significantly lower after surgery. These data suggest a relationship between cholinergic activity and the secretory response of mast cells and indicates a correlation between the parasympathetic nerve supply and chronic hyperthrophic non-allergic rhinitis. The significant reduction in mast cell density, histamine levels and histidine-decarboxylase activity also lends support to the hypothesis that the parasympathetic nerve supply plays a role in the regulation of mast cell histamine.
鼻黏膜呼吸道的副交感神经支配在慢性肥厚性非过敏性鼻炎（C.H.N.A.R.）的发病机制中起重要作用，翼管神经为呼吸道黏膜提供主要的副交感神经供应。本研究调查了22例难治性C.H.N.A.R.患者行翼管神经切除术后对呼吸道中组胺含量与生成、肥大细胞数量及其脱颗粒的影响。在翼管神经切除术前以及术后12 - 24个月，从呼吸道黏膜取材进行组胺和组氨酸脱羧酶测定，并进行显微镜观察以评估肥大细胞密度和脱颗粒指数。通过鼻阻力测量法评估，翼管神经切除术完全治愈了临床症状，并且还显著降低了C.H.N.A.R.患者的高组胺水平和组氨酸脱羧酶活性。术后肥大细胞的密度和脱颗粒指数也显著降低。这些数据表明胆碱能活性与肥大细胞的分泌反应之间存在关联，并表明副交感神经供应与慢性肥厚性非过敏性鼻炎之间存在相关性。肥大细胞密度、组胺水平和组氨酸脱羧酶活性的显著降低也支持了副交感神经供应在调节肥大细胞组胺方面起作用的假说。
