Masini E, Rucci L, Cirri-Borghi M B, Giannella E, Mannaioni P F
Agents Actions. 1986 Apr;18(1-2):251-3. doi: 10.1007/BF01988034.
Parasympathetic innervation of nasal mucosa plays an important role in the pathogenesis of chronic hypertrophic non-allergic rhinitis (C.H.N.A.R.). The present study investigated the effect of Vidian nerve stimulation and resection on the histamine contents and on the morphological pattern in mucosal samples of patients with C.H.N.A.R. Vidian nerve stimulation determines a significant decrease in histamine content in the samples examined; microscopical observations showed significant variations in the glandular, stromal and vascular components. The changes indicate an enhanced secretory activity, intensive vasodilatation and active degranulation of mast cells, which were significantly decreased in number in the samples obtained after 90 sec of stimulation. The neurectomy of the Vidian nerve resolves quite completely the clinical symptomatology and in parallel decreases the mucosal histamine contents, which are increased in patients with C.H.N.A.R. before the operation in comparison with the normal controls.
鼻黏膜的副交感神经支配在慢性肥厚性非过敏性鼻炎（C.H.N.A.R.）的发病机制中起重要作用。本研究调查了翼管神经刺激和切除对C.H.N.A.R.患者黏膜样本中组胺含量及形态模式的影响。翼管神经刺激可使所检测样本中的组胺含量显著降低；显微镜观察显示腺、基质和血管成分有显著变化。这些变化表明分泌活动增强、血管强烈扩张以及肥大细胞活跃脱颗粒，在刺激90秒后获取的样本中肥大细胞数量显著减少。翼管神经切除术可相当完全地缓解临床症状，同时降低黏膜组胺含量，C.H.N.A.R.患者术前的黏膜组胺含量相较于正常对照有所增加。
