Fenercioglu Aysen Kutan, Unal Durisehvar Ozer
Department of Family Medicine, Cerrahpasa Medical Faculty, Istanbul University - Cerrahpasa, Istanbul, Turkey.
Department of Analytical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Cardiovasc Toxicol. 2025 Aug 17. doi: 10.1007/s12012-025-10054-y.
Endocrine disrupting chemicals (EDCs) are exogenous compounds that interfere with the normal functioning of the endocrine system. This effect is crucial for maintaining hormonal balance and regulating various physiological processes. Phthalates, parabens, and triclosan are EDCs found in many personal care products (make-up, shampoo, perfume, shaving foam, moisturizing cream, hair dyes, deodorant), plastics, pesticides, pharmaceuticals, and household cleaning products, and can be inhaled or absorbed by the body through inhalation or skin contact. Atherosclerosis is a major cause of cardiovascular diseases, including coronary artery disease, stroke, and peripheral artery disease. While traditional risk factors for atherosclerosis, such as high cholesterol, hypertension, and smoking, have been extensively studied, emerging evidence suggests that EDCs may also play a significant role in the development and progression of atherosclerosis. Several potential mechanisms have been proposed to explain how EDCs contribute to atherosclerosis. One mechanism involves the activation of nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and estrogen receptors (ERs), by EDCs. Activation of these receptors can lead to dysregulation of lipid metabolism, inflammation, and oxidative stress, all of which are key processes in atherosclerosis development. EDCs have been shown to disrupt endothelial function through various mechanisms. Some of these mechanisms are the formation of reactive oxygen species (ROS) and free oxygen radicals, and impaired nitric oxide (NO) production by EDCs. This literature review aims to explore the current understanding of the role of EDCs in atherosclerosis.
内分泌干扰化学物质（EDCs）是干扰内分泌系统正常功能的外源性化合物。这种作用对于维持激素平衡和调节各种生理过程至关重要。邻苯二甲酸盐、对羟基苯甲酸酯和三氯生是在许多个人护理产品（化妆品、洗发水、香水、剃须泡沫、保湿霜、染发剂、除臭剂）、塑料制品、农药、药品和家用清洁产品中发现的内分泌干扰化学物质，可通过吸入或皮肤接触被人体吸入或吸收。动脉粥样硬化是心血管疾病的主要原因，包括冠状动脉疾病、中风和外周动脉疾病。虽然动脉粥样硬化的传统危险因素，如高胆固醇、高血压和吸烟，已得到广泛研究，但新出现的证据表明，内分泌干扰化学物质可能在动脉粥样硬化的发生和发展中也起重要作用。已经提出了几种潜在机制来解释内分泌干扰化学物质如何导致动脉粥样硬化。一种机制涉及内分泌干扰化学物质激活核受体，如过氧化物酶体增殖物激活受体（PPARs）和雌激素受体（ERs）。这些受体的激活可导致脂质代谢、炎症和氧化应激失调，所有这些都是动脉粥样硬化发展中的关键过程。内分泌干扰化学物质已被证明通过多种机制破坏内皮功能。其中一些机制是活性氧（ROS）和游离氧自由基的形成，以及内分泌干扰化学物质对一氧化氮（NO）生成的损害。这篇文献综述旨在探讨目前对内分泌干扰化学物质在动脉粥样硬化中作用的理解。
