Lemini Cristina, Silveyra Patricia, Segovia-Mendoza Mariana
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Department of Environmental and Occupational Health, Indiana University Bloomington, School of Public Health, Bloomington, IN, USA.
Environ Toxicol Pharmacol. 2024 Apr;107:104407. doi: 10.1016/j.etap.2024.104407. Epub 2024 Feb 28.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. CVDs are promoted by the accumulation of lipids and immune cells in the endothelial space resulting in endothelial dysfunction. Endothelial cells are important components of the vascular endothelium, that regulate the vascular flow. The imbalance in the production of vasoactive substances results in the loss of vascular homeostasis, leading the endothelial dysfunction. Thus, endothelial dysfunction plays an essential role in the development of atherosclerosis and can be triggered by different cardiovascular risk factors. On the other hand, the 17β-estradiol (E2) hormone has been related to the regulation of vascular tone through different mechanisms. Several compounds can elicit estrogenic actions similar to those of E2. For these reasons, they have been called endocrine-disrupting compounds (EDCs). This review aims to provide up-to-date information about how different EDCs affect endothelial function and their mechanistic roles in the context of CVDs.
心血管疾病（CVDs）是全球首要死因。脂质和免疫细胞在内皮间隙的积聚促进了心血管疾病的发生发展，进而导致内皮功能障碍。内皮细胞是血管内皮的重要组成部分，负责调节血管血流。血管活性物质产生的失衡会导致血管稳态的丧失，进而引发内皮功能障碍。因此，内皮功能障碍在动脉粥样硬化的发展过程中起着至关重要的作用，并且可能由不同的心血管危险因素引发。另一方面，17β-雌二醇（E2）激素通过不同机制与血管张力的调节有关。几种化合物可以引发与E2类似的雌激素作用。出于这些原因，它们被称为内分泌干扰化合物（EDCs）。本综述旨在提供有关不同EDCs如何影响内皮功能及其在心血管疾病背景下的作用机制的最新信息。
