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了解你的敌人:认识蚊子生物学以推动非洲消除疟疾

Know your enemy: understanding mosquito biology to advance malaria elimination in Africa.

作者信息

Zembere Kennedy, Kalonde Patrick Ken, Bickton Fanuel Meckson

机构信息

Malawi-Liverpool-Wellcome Programme, Blantyre, Malawi.

Liverpool School of Tropical Medicine, Liverpool, UK.

出版信息

Parasitol Res. 2025 Aug 18;124(8):93. doi: 10.1007/s00436-025-08534-9.

DOI:10.1007/s00436-025-08534-9
PMID:40824459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361305/
Abstract

Over a century has passed since the discovery that the female anopheline mosquito is a vector of malaria, prompting extensive efforts to combat the disease. Vector control remains the primary malaria prevention strategy, accounting for a remarkable 65% reduction in malaria cases between 2000 and 2015. A thorough understanding of the fundamental biology of malaria vectors is essential for national malaria control programmes, governments, and local communities to implement sustainable and effective vector control measures. This article explores the key aspects of mosquito biology, such as adult and juvenile life stages, the intrinsic incubation period, and blood-seeking behaviour, within the context of the mosquito life cycle. By emphasizing the importance of this knowledge, we illustrate how it can inform community-level control initiatives and guide national programmes in designing more effective interventions for vector-borne disease management. Furthermore, the article underscores how researchers can harness these biological insights to develop and deploy innovative tools that have the potential to revolutionize malaria control efforts.

摘要

自发现雌性按蚊是疟疾的传播媒介以来,已经过去了一个多世纪,这促使人们为抗击这种疾病付出了巨大努力。病媒控制仍然是主要的疟疾预防策略,在2000年至2015年间,疟疾病例显著减少了65%。全面了解疟疾传播媒介的基本生物学特性,对于国家疟疾控制项目、政府和当地社区实施可持续且有效的病媒控制措施至关重要。本文在蚊子生命周期的背景下,探讨了蚊子生物学的关键方面,如成虫和幼虫阶段、内在潜伏期以及吸血行为。通过强调这些知识的重要性,我们阐述了它如何为社区层面的控制举措提供信息,并指导国家项目设计更有效的病媒传播疾病管理干预措施。此外,本文强调了研究人员如何利用这些生物学见解来开发和部署创新工具,这些工具有可能彻底改变疟疾控制工作。

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本文引用的文献

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Attractive targeted sugar baits for malaria control in western Kenya (ATSB-Kenya) - Effect of ATSBs on epidemiologic and entomologic indicators: A Phase III, open-label, cluster-randomised, controlled trial.肯尼亚西部用于疟疾控制的靶向性诱蚊糖饵(ATSB-肯尼亚)——ATSB对流行病学和昆虫学指标的影响:一项III期、开放标签、整群随机对照试验
PLOS Glob Public Health. 2025 Jun 26;5(6):e0004230. doi: 10.1371/journal.pgph.0004230. eCollection 2025.
2
The potential for attractive toxic sugar baits to complement core malaria interventions strategies: the need for more evidence.有潜力的具有吸引力的毒性糖诱饵来补充核心疟疾干预策略:需要更多的证据。
Malar J. 2024 Nov 23;23(1):356. doi: 10.1186/s12936-024-05161-0.
3
Analysis of the 24-h biting patterns and human exposures to malaria vectors in south-eastern Tanzania.分析坦桑尼亚东南部 24 小时蚊虫叮咬模式和人类疟疾媒介的暴露情况。
Parasit Vectors. 2024 Oct 30;17(1):445. doi: 10.1186/s13071-024-06521-0.
4
Malaria vector control in sub-Saharan Africa: complex trade-offs to combat the growing threat of insecticide resistance.撒哈拉以南非洲的疟疾媒介控制:应对杀虫剂耐药性日益增长威胁的复杂权衡。
Lancet Planet Health. 2024 Oct;8(10):e804-e812. doi: 10.1016/S2542-5196(24)00172-4.
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New directions for malaria vector control using geography and geospatial analysis.利用地理和地理空间分析促进疟疾媒介控制的新方向。
Adv Parasitol. 2024;125:1-52. doi: 10.1016/bs.apar.2024.06.001. Epub 2024 Jun 26.
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Prehabilitation in patients with cirrhosis awaiting liver transplantation: protocol of a feasibility study.肝硬化患者肝移植术前康复治疗的可行性研究方案。
BMJ Open. 2024 Jun 25;14(6):e081362. doi: 10.1136/bmjopen-2023-081362.
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Genetic surveillance of insecticide resistance in African Anopheles populations to inform malaria vector control.对非洲按蚊种群中杀虫剂抗性的遗传监测,以提供疟疾病媒控制信息。
Trends Parasitol. 2024 Jul;40(7):604-618. doi: 10.1016/j.pt.2024.04.016. Epub 2024 May 16.
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The paradox of plant preference: The malaria vectors and select suboptimal food sources for their survival and reproduction.植物偏好的悖论:疟蚊选择次优食物来源以维持生存和繁殖。
Ecol Evol. 2024 Mar 25;14(3):e11187. doi: 10.1002/ece3.11187. eCollection 2024 Mar.
9
Community engagement approaches for malaria prevention, control and elimination: a scoping review.社区参与方法在疟疾预防、控制和消除中的应用:综述
BMJ Open. 2024 Feb 15;14(2):e081982. doi: 10.1136/bmjopen-2023-081982.
10
Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication.建立杀虫剂处理蚊帐资源分配策略模型以实现疟疾消除。
Elife. 2024 Feb 8;12:RP88283. doi: 10.7554/eLife.88283.