von Ardenne M
Z Alternsforsch. 1984 Jul-Aug;39(4):187-210.
The routine determination of the oxygen flux into body's tissues (= resting oxygen uptake) should gain more attention in practice, because its magnitude can be considered a kind of characteristic value for the energetic state of the entire organism. The determination of this value has deserved special interest since we discouvered a "switch mechanism" of blood microcirculation, which depends on the oxygen state of the body. A high value of pO2 (greater than or equal to 50 mm of Hg) at the venous ends of the capillaries, attainable by the procedures of the Oxygen Multistep Therapy and by powerful physical exercise as well, results in an increase of the blood microcirculation and, consequently, in a permanent elevation of the oxygen influx and uptake, respectively. This effect can persist for weeks, months or even years. If the oxygen state gets worse and declines below a certain threshold, e. g. in progressing age or after long-term distress, the cross sections of the capillaries shrink by swelling of the endothelial cells, and the blood microcirculation is diminished for an extended period of time. The utilization of the above-mentioned switch mechanism for permanent improvement of the oxygen flux into all the tissues of the organism is therefore of decisive importance for fighting against the common cause of many diseases, disorders and complaints going often along with increasing age due to insufficient oxygen (energy) supply for general metabolism. As can be taken from measurements described in this paper, the main contribution to this deterioraction comes from the age-dependent diminution of the cardiac minute or stroke volume, respectively, since eta--the percent exhaustion of the oxygen-binding capacity of blood--increases even with progressing age, as was found by us. Numerous determinations of the arterial and venous pO2 resting levels have shown that the values of eta can almost be doubled easily by the procedures of the Oxygen Multistep Therapy, whereby--as a rule--the age-dependent decrease of the cardiac output is overcompensated. Within the schedule of the Oxygen Multistep Therapy, the third step prescribes a temporary enhancement of the blood circulation by physical exercise. With respect to this measure, there was made progress of principal importance by the idea to increase the minute volume by application of sympathicomimetics during the single treatment units under moderately enhanced oxygen inhalation, but with due consideration of the known contraindications.(ABSTRACT TRUNCATED AT 400 WORDS)
在实际应用中，常规测定进入人体组织的氧通量（即静息氧摄取量）应得到更多关注，因为其大小可被视为整个机体能量状态的一种特征值。自从我们发现了一种依赖于机体氧状态的血液微循环“开关机制”以来，对该值的测定就值得特别关注。通过氧多步疗法以及剧烈体育锻炼，在毛细血管静脉端可达到较高的pO2值（大于或等于50毫米汞柱），这会导致血液微循环增加，进而分别使氧流入量和摄取量持续升高。这种效果可持续数周、数月甚至数年。如果氧状态变差并降至某个阈值以下，例如随着年龄增长或长期处于应激状态，毛细血管横截面积会因内皮细胞肿胀而缩小，血液微循环会在较长时间内减少。因此，利用上述开关机制来永久改善进入机体所有组织的氧通量，对于对抗许多与年龄增长相关的疾病、紊乱和不适的常见病因具有决定性意义，这些病因通常是由于全身代谢的氧（能量）供应不足所致。从本文所述的测量结果可以看出，这种恶化的主要原因分别是与年龄相关的心输出量或每搏输出量的减少，因为正如我们所发现的，即使随着年龄增长，血液氧结合能力的耗尽百分比（η）也会增加。对动脉和静脉静息pO2水平的大量测定表明，通过氧多步疗法，η值几乎可以轻松翻倍，通常情况下，这会使与年龄相关的心输出量下降得到过度补偿。在氧多步疗法方案中，第三步规定通过体育锻炼暂时增强血液循环。关于这一措施，一个具有重要意义的进展是提出在适度增加吸氧的单次治疗单元期间，应用拟交感神经药来增加心输出量，但要适当考虑已知的禁忌症。
