Kirton Michael James, Cox Emily R, Dalleck Lance, Lange Belinda, Drummond Claire, Chakraborty Ranjay, Beleigoli Alline, Ramos Joyce S
College of Nursing and Health Sciences, Caring Futures Institute, Flinders University, Adelaide, SA, Australia.
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
JMIR Res Protoc. 2025 Aug 19;14:e65935. doi: 10.2196/65935.
The prevalence of neurodegenerative conditions is expected to continue to rise, with current treatments largely focused on the management of symptoms and not disease progression. Exercise is a therapy that has significant favorable effects on several of the modifiable risk factors that influence the development/progression of some neurodegenerative conditions. However, there are significant barriers to exercise for this population, warranting consideration of alternative or adjunct therapies. Blood plasma transfusion is an emerging nonpharmaceutical/nonexercise therapy that may have positive benefits on people and animal models with neurodegenerative conditions.
The aim of this study was to investigate and synthesize the literature on the impacts of young or exercised blood plasma transfusions in people and animal models with neurodegenerative conditions.
We will include studies that have explored the impacts of young or exercised blood plasma transfusions in adults or animal models with neurodegenerative conditions. PubMed Central, MEDLINE, Cochrane Database of Systematic Reviews, Scopus, ProQuest, SPORTDiscus, PROSPERO, and multiple unpublished sources, including book chapters, conference papers, and theses, will be searched to include literature from January 2004 to May 2024, written in English. Studies will be screened by 2 independent reviewers; a third reviewer will be used to resolve any conflicts. Data will be extracted into a modified charting tool and will be presented in a graphical or tabular format combined with the appropriate narration.
As of June 2024, the literature search has been completed. After searching listed databases, 3646 citations and 13 gray literature studies were identified, of which 1432 duplicates were removed.
To the best of our knowledge, this study will be the first study with the aim of investigating the literature on the impacts of young or exercised blood plasma transfusions in individuals with neurodegenerative conditions.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/65935.
神经退行性疾病的患病率预计将持续上升，目前的治疗主要集中在症状管理而非疾病进展方面。运动是一种对影响某些神经退行性疾病发展/进展的多种可改变风险因素具有显著积极作用的疗法。然而，这一人群进行运动存在重大障碍，因此有必要考虑替代疗法或辅助疗法。血浆输注是一种新兴的非药物/非运动疗法，可能对患有神经退行性疾病的人和动物模型产生积极益处。
本研究旨在调查和综合有关年轻或运动血浆输注对患有神经退行性疾病的人和动物模型影响的文献。
我们将纳入探讨年轻或运动血浆输注对患有神经退行性疾病的成人或动物模型影响的研究。将检索美国国立医学图书馆的生物医学与健康科学期刊数据库、医学索引数据库、考克兰系统评价数据库、Scopus数据库、ProQuest数据库、体育与运动科学数据库、国际系统评价注册库以及多个未发表来源，包括书籍章节、会议论文和学位论文，以纳入2004年1月至2024年5月期间用英文撰写的文献。研究将由2名独立评审员进行筛选；如有任何冲突，将由第三名评审员解决。数据将提取到一个修改后的图表工具中，并将以图形或表格形式呈现，并配有适当的叙述。
截至2024年6月，文献检索已完成。在检索所列数据库后，共识别出3646条引文和13项灰色文献研究，其中删除了1432条重复项。
据我们所知，本研究将是第一项旨在调查年轻或运动血浆输注对患有神经退行性疾病个体影响的文献研究。
国际注册报告识别号（IRRID）：DERR1-10.2196/65935
