乍得首都抗新冠病毒抗体的高血清阳性率。
High seroprevalence of anti-SARS-CoV-2 antibodies in the capital of Chad.
作者信息
Deutou Wondeu Andrillene Laure, Abdelrazakh Fatima, Abakar Mahamat Fayiz, Yandai Fissou Henry, Nodjikouambaye Aleyo Zita, Djimtoibaye Djallaye, Kimala Pidou, Nadjiadjim Noel, Naïbeï Nathan, Takoudjou Dzomo Guy Rodrigue, Atturo Sabrina, Linardos Giulia, Russo Cristina, Perno Carlo Federico, Moussa Ali Mahamat, Yokouide Allarangar, Tchidjou Hyppolite Kuekou, Colizzi Vittorio, Choua Ouchemi
机构信息
Major Tropical Epidemics Laboratory LAGET, Good Samaritan University Hospital Centre, N'Djamena, Chad.
Lab. of Molecular Biology, Immunopathology, Evangelical University of Cameroon, Mbouo-Bandjoun, Cameroon.
出版信息
J Public Health Afr. 2023 Jan 11;13(4):2255. doi: 10.4081/jphia.2022.2255. eCollection 2022 Dec 31.
BACKGROUND
Since the start of the COVID-19 pandemic, Chad has had 7,417 confirmed cases and 193 deaths, one of the lowest in Africa.
OBJECTIVE
This study assessed SARS-CoV-2 immunity in N'Djamena.
METHODS
In August-October 2021, eleven N'Djamena hospitals collected outpatient data and samples. IgG antibodies against SARSCoV- 2 nucleocapsid protein were identified using ELISA. "Bambino Gesù" Laboratory, Rome, Italy, performed external quality control with chemiluminescence assay.
RESULTS
25-34-year-old (35.2%) made up the largest age group at 31.912.6 years. 56.4% were women, 1.3 women/men. The 7 district had 22.5% and the 1st 22.3%. Housewives and students dominated. Overall seroprevalence was 69.5% (95% CI: 67.7-71.3), females 68.2% (65.8-70.5) and males 71.2% (68.6-73.8). >44-year-old had 73.9% seroprevalence. Under-15s were 57.4% positive. Housewives (70.9%), civil servants (71.5%), and health workers (9.7%) had the highest antibody positivity. N'Djamena's 9 district had 73.1% optimism and the 3rd district had 52.5%. Seroprevalences were highest at Good Samaritan Hospital (75.4%) and National General Referral Hospital (74.7%).
CONCLUSION
Our findings indicate a high circulation of SARSCoV- 2 in N'Djamena, despite low mortality and morbidity after the first two COVID-19 pandemic waves. This high seroprevalence must be considered in Chad's vaccine policy.
背景
自新冠疫情开始以来，乍得已报告7417例确诊病例和193例死亡病例，是非洲确诊病例和死亡病例数最低的国家之一。
目的
本研究评估了恩贾梅纳市的新冠病毒免疫力。
方法
2021年8月至10月，恩贾梅纳市的11家医院收集了门诊数据和样本。采用酶联免疫吸附测定法（ELISA）检测针对新冠病毒核衣壳蛋白的IgG抗体。意大利罗马的“圣婴医院”实验室采用化学发光分析法进行外部质量控制。
结果
年龄在25 - 34岁之间的人群占比最大（35.2%），平均年龄为31.9 ± 12.6岁。女性占56.4%，男女比例为1.3∶1。第7区占22.5%，第1区占22.3%。家庭主妇和学生占主导。总体血清阳性率为69.5%（95%置信区间：67.7 - 71.3），女性为68.2%（65.8 - 70.5），男性为71.2%（68.6 - 73.8）。44岁以上人群的血清阳性率为73.9%。15岁以下儿童的阳性率为57.4%。家庭主妇（70.9%）、公务员（71.5%）和医护人员（9.7%）的抗体阳性率最高。恩贾梅纳市第9区的血清阳性率为73.1%，第3区为52.5%。撒玛利亚医院（75.4%）和国家综合转诊医院（74.7%）的血清阳性率最高。
结论
我们的研究结果表明，尽管在新冠疫情的前两波中死亡率和发病率较低，但恩贾梅纳市的新冠病毒传播率很高。在乍得制定疫苗政策时，必须考虑到这一高血清阳性率。
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