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Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies.

作者信息

Gao Le, Sun Jiajun, Zhang Zhaokun, Wu Xin

机构信息

State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Technology Innovation Center for Synthetic Biology, Tianjin, 300308, China.

出版信息

Sci China Life Sci. 2025 Aug 13. doi: 10.1007/s11427-025-3005-3.

DOI:10.1007/s11427-025-3005-3
PMID:40833708
Abstract
摘要

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本文引用的文献

1
Advances and trends for astaxanthin synthesis in Phaffia rhodozyma.红发夫酵母中虾青素合成的进展与趋势
Microb Cell Fact. 2025 May 6;24(1):100. doi: 10.1186/s12934-025-02704-1.
2
The bioproduction of astaxanthin: A comprehensive review on the microbial synthesis and downstream extraction.虾青素的生物生产：微生物合成及下游提取的综合评述
Biotechnol Adv. 2024 Sep;74:108392. doi: 10.1016/j.biotechadv.2024.108392. Epub 2024 May 31.
3
Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica.
靶向途径表达至亚细胞细胞器可提高解脂耶氏酵母中虾青素的合成。
Metab Eng. 2021 Nov;68:152-161. doi: 10.1016/j.ymben.2021.10.004. Epub 2021 Oct 9.
4
Overexpression of ZWF1 and POS5 improves carotenoid biosynthesis in recombinant Saccharomyces cerevisiae.ZWF1和POS5的过表达改善了重组酿酒酵母中的类胡萝卜素生物合成。
Lett Appl Microbiol. 2015 Oct;61(4):354-60. doi: 10.1111/lam.12463. Epub 2015 Aug 13.
5
Biotechnological production of astaxanthin with Phaffia rhodozyma/Xanthophyllomyces dendrorhous.利用红发夫酵母/雨生红球藻生产虾青素的生物技术。
Appl Microbiol Biotechnol. 2011 Feb;89(3):555-71. doi: 10.1007/s00253-010-2976-6. Epub 2010 Nov 3.
6
Influence of Oxygen and Glucose on Primary Metabolism and Astaxanthin Production by Phaffia rhodozyma in Batch and Fed-Batch Cultures: Kinetic and Stoichiometric Analysis.氧和葡萄糖对红球藻分批和补料分批培养中初级代谢和虾青素生产的影响：动力学和化学计量分析。
Appl Environ Microbiol. 1997 Nov;63(11):4471-8. doi: 10.1128/aem.63.11.4471-4478.1997.
7
The steady-state internal redox state (NADH/NAD) reflects the external redox state and is correlated with catabolic adaptation in Escherichia coli.稳态内部氧化还原状态（NADH/NAD）反映了外部氧化还原状态，并与大肠杆菌中的分解代谢适应性相关。
J Bacteriol. 1999 Apr;181(8):2351-7. doi: 10.1128/JB.181.8.2351-2357.1999.