兔免疫球蛋白重链Fd片段中的同种异型相关序列。
Allotypically related sequences in the Fd fragment of rabbit immunoglobulin heavy chains.
作者信息
Mole L E, Jackson S A, Porter R R, Wilkinson J M
出版信息
Biochem J. 1971 Sep;124(2):301-18. doi: 10.1042/bj1240301.
Abstract
The sequence has been completed of the N-terminal 94 residues of the variable section of the Fd fragment of heavy chains from rabbit immunoglobulin G (IgG) of allotype As1. Most of the sequence of the same section from IgG of allotype Aa3 is also reported. These results, in conjunction with a substantial sequence of the variable region of allotype Aa2 reported elsewhere (Fleischman, 1971), show the presence of 16 positions (including six consecutive positions) in which the residue present correlates with the allotype. No allotype-related sequence variation has been found in the constant section of the Fd fragment. This evidence supports the view that two genes code for the heavy chain and it can be used as evidence in favour of somatic mutation as the origin of the variability in the sequence of the N-terminal section. The evolutionary origin of the ;a' locus allotypes of rabbit immunoglobulins remains obscure.
摘要
已完成对同种异型As1的兔免疫球蛋白G（IgG）重链Fd片段可变区N端94个残基的测序。还报道了同种异型Aa3的IgG相同区段的大部分序列。这些结果，连同其他地方报道的同种异型Aa2可变区的大量序列（弗莱施曼，1971年），表明存在16个位置（包括六个连续位置），其中存在的残基与同种异型相关。在Fd片段的恒定区未发现与同种异型相关的序列变异。这一证据支持了两个基因编码重链的观点，并且可以用作支持体细胞突变是N端区段序列变异性起源的证据。兔免疫球蛋白“a”位点同种异型的进化起源仍然不明。
相似文献
1
Allotypically related sequences in the Fd fragment of rabbit immunoglobulin heavy chains.兔免疫球蛋白重链Fd片段中的同种异型相关序列。
Biochem J. 1971 Sep;124(2):301-18. doi: 10.1042/bj1240301.
2
Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype.不同同种异型兔免疫球蛋白G重链N端序列的变异
Biochem J. 1969 Apr;112(2):173-85. doi: 10.1042/bj1120173.
3
Sequence studies on the constant region of the Fd sections of rabbit immunoglobulin G of different allotype.不同同种异型兔免疫球蛋白G的Fd片段恒定区的序列研究。
Biochem J. 1975 Nov;151(2):337-49. doi: 10.1042/bj1510337.
4
Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2.同种异型α2抗肺炎球菌免疫球蛋白重链N端区域的部分氨基酸序列
Biochem J. 1974 Apr;139(1):281-3. doi: 10.1042/bj1390281.
5
Amino acid sequence of the N-terminal sixty-nine residues of heavy chain derived from a homogeneous rabbit antibody.源自一种纯合兔抗体的重链N端69个残基的氨基酸序列。
Biochem J. 1972 Nov;130(2):539-46. doi: 10.1042/bj1300539.
6
Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.兔免疫球蛋白 G 重链同种异型相关序列变异。
Biochem J. 1968 May;107(6):753-63. doi: 10.1042/bj1070753.
7
Sequence studies of the Fd section of the heavy chain of rabbit immunoglobulin G.兔免疫球蛋白G重链Fd段的序列研究
Biochem J. 1970 Jan;116(2):249-59. doi: 10.1042/bj1160249.
8
9
The partial sequence of two large peptides from the N-terminal half of heavy chains from normal rabbit immunoglobulin G.来自正常兔免疫球蛋白G重链N端半段的两个大肽段的部分序列。
Biochem J. 1968 Mar;107(1):79-88. doi: 10.1042/bj1070079.
引用本文的文献
1
Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.H-2 限制性 T 细胞的抗原识别。I. 无细胞抗原处理。
J Exp Med. 1983 Aug 1;158(2):303-16. doi: 10.1084/jem.158.2.303.
2
Detection of idiotypic cross-reactions among streptococcal antisera from related rabbits.相关兔源链球菌抗血清中独特型交叉反应的检测
J Exp Med. 1973 Sep 1;138(3):522-37. doi: 10.1084/jem.138.3.522.
3
Phenogroups and quantitative allelic expression for rabbit serum 2 -macroglobulin allotypes.兔血清α2-巨球蛋白同种异型的表型组和定量等位基因表达。
Biochem Genet. 1973 Feb;8(2):175-86. doi: 10.1007/BF00485545.
4
Intrachain disulphide bridges of rabbit immunoglobulin light chains of allotypes b4 and b5.同种异型b4和b5兔免疫球蛋白轻链的链内二硫键桥
Biochem J. 1972 Aug;128(5):1357-9. doi: 10.1042/bj1281357.
5
The oligosaccharide units of rabbit immunoglobulin G. Multiple carbohydrate attachment sites.兔免疫球蛋白G的寡糖单位。多个碳水化合物附着位点。
Biochem J. 1972 May;127(5):757-65. doi: 10.1042/bj1270757.
6
Polypeptide formation and polyribosomes in Escherichia coli treated with chloramphenicol.氯霉素处理的大肠杆菌中的多肽形成与多核糖体
J Bacteriol. 1974 May;118(2):582-9. doi: 10.1128/jb.118.2.582-589.1974.
7
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.VH3亚组的五条人免疫球蛋白重链的可变区序列：四个重链高变区的明确鉴定
Proc Natl Acad Sci U S A. 1974 Mar;71(3):845-8. doi: 10.1073/pnas.71.3.845.
8
Affinity labelling of the binding site of rabbit antibody. Evidence for the involvement of the hypervariable regions of the heavy chain.兔抗体结合位点的亲和标记。重链高变区参与的证据。
Biochem J. 1974 Apr;139(1):135-49. doi: 10.1042/bj1390135.
9
Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2.同种异型α2抗肺炎球菌免疫球蛋白重链N端区域的部分氨基酸序列
Biochem J. 1974 Apr;139(1):281-3. doi: 10.1042/bj1390281.
10
Amino acid sequence of the N-terminal sixty-nine residues of heavy chain derived from a homogeneous rabbit antibody.源自一种纯合兔抗体的重链N端69个残基的氨基酸序列。
Biochem J. 1972 Nov;130(2):539-46. doi: 10.1042/bj1300539.
本文引用的文献
1
Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.兔免疫球蛋白 G 重链同种异型相关序列变异。
Biochem J. 1968 May;107(6):753-63. doi: 10.1042/bj1070753.
2
ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.论遗传精细结构的拓扑学
Proc Natl Acad Sci U S A. 1961 Mar;47(3):403-15. doi: 10.1073/pnas.47.3.403.
3
CHARACTER AND ALLOTYPY OF AN IMMUNE GLOBULIN IN RABBIT COLOSTRUM.兔初乳中免疫球蛋白的特性与同种异型
Nature. 1963 Sep 21;199:1197-9. doi: 10.1038/1991197b0.
4
Allotypy in rabbit 19S protein.兔19S蛋白中的同种异型
Biochem Biophys Res Commun. 1963 May 3;11:170-5. doi: 10.1016/0006-291x(63)90329-2.
5
Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.兔血清蛋白的同种异型。I. 免疫化学分析确定七种主要同种异型的个体差异
J Exp Med. 1960 Jul 1;112(1):107-24. doi: 10.1084/jem.112.1.107.
6
A method for purifying methionine-containing peptides by radioactive labelling.一种通过放射性标记纯化含甲硫氨酸肽的方法。
FEBS Lett. 1969 Aug;4(3):170-172. doi: 10.1016/0014-5793(69)80226-7.
7
A diagonal electrophoretic method for selective purification of methionine peptides.一种用于选择性纯化甲硫氨酸肽的对角线电泳方法。
Biochem J. 1967 Feb;102(2):593-9. doi: 10.1042/bj1020593.
8
Reversible blocking of amino groups with citraconic anhydride.用柠康酸酐对氨基进行可逆封闭。
Biochem J. 1968 Sep;109(2):312-4. doi: 10.1042/bj1090312.
9
An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity.本斯·琼斯蛋白和骨髓瘤轻链可变区序列分析及其对抗体互补性的影响。
J Exp Med. 1970 Aug 1;132(2):211-50. doi: 10.1084/jem.132.2.211.
10
Variability in the lambda light chain sequences of mouse antibody.小鼠抗体λ轻链序列的变异性
Nature. 1970 Dec 12;228(5276):1045-7. doi: 10.1038/2281045a0.
Zotero 插件