Tanaka N, Ryden S, Bergqvist L, Christensen P, Bengmark S
Br J Surg. 1985 Dec;72(12):946-9. doi: 10.1002/bjs.1800721204.
Reticulo-endothelial function was evaluated by measuring the biokinetics of a standardized 99mTc-sulphur colloid using scintillation camera technique in rats with biliary obstruction. There was no difference in the uptake of the colloid in the liver (K1) between sham operation and biliary obstruction at 1 week and 3 weeks. However, when corrected for changes in liver volume, the corrected colloidal uptake rate (cK1) of the liver was significantly decreased in 1 week's biliary obstruction (P less than 0.005 compared with sham operation) and 3 weeks' biliary obstruction (P less than 0.025 compared with 1 week obstruction). Colloidal uptake rate of the extrahepatic reticulo-endothelial system (K2) was significantly increased (P less than 0.005) in rats with 3 weeks' biliary obstruction. Activity distribution of 99mTc-sulphur colloid in 3 weeks' biliary obstruction was significantly decreased in both total organ basis and per gram basis (P less than 0.005). The results demonstrated a depression of RE activity of the liver in biliary obstruction.
采用闪烁照相机技术，通过测量标准化的99mTc-硫胶体在胆管梗阻大鼠体内的生物动力学，评估网状内皮系统功能。在假手术组与胆管梗阻1周和3周的大鼠之间，肝脏对胶体的摄取（K1）无差异。然而，校正肝脏体积变化后，胆管梗阻1周时肝脏的校正胶体摄取率（cK1）显著降低（与假手术组相比，P<0.005），胆管梗阻3周时也显著降低（与梗阻1周组相比，P<0.025）。在胆管梗阻3周的大鼠中，肝外网状内皮系统的胶体摄取率（K2）显著增加（P<0.005）。在胆管梗阻3周时，99mTc-硫胶体在全器官和每克基础上的活性分布均显著降低（P<0.005）。结果表明，胆管梗阻时肝脏的网状内皮系统活性降低。
