Suppr超能文献

聚焦式体外冲击波疗法治疗膝骨关节炎的疗效:一项临床试验研究。

The Efficacy of Focused Extracorporeal Shockwave Therapy for the Knee Osteoarthritis: A Clinical Trial Study.

作者信息

Vahdatpour Babak, Mortazavi Faezeh Sadat, Haghighat Shila, Saleki Mehrjerdi Mohammad, Mortazavi Zahra Sadat

机构信息

Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Orthopedics, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2025 Jul 21;14:56. doi: 10.4103/abr.abr_202_21. eCollection 2025.

Abstract

BACKGROUND

Osteoarthritis is the most common form of degenerative arthritis. To date, varieties of management approaches have been recommended for osteoarthritis, but their outcomes are not consistent. In the current study, it is aimed to assess the efficacy of focused shockwave therapy for the treatment of knee osteoarthritis.

MATERIALS AND METHODS

The current randomized clinical trial was conducted on 42 patients (22 cases and 20 controls, with mean age of 58.02 ± 9.90 years) with knee osteoarthritis in 2018-2019, in Isfahan, Iran. Both groups received topical analgesic plus hot pack and celecoxib 200 mg 14d. The cases underwent shockwave therapy, whereas the controls underwent sham shockwave therapy. Pain score based on visual analog scale (VAS), Knee injury and Outcome Osteoarthritis Score (KOOS) and Roles and Maudsley scores were assessed basically and within 12 weeks.

RESULTS

Disease-related symptoms (as a part of KOOS questionnaire) improved following the interventions in both groups ( < 0.05) but the comparison between groups found no significant differences, whereas daily activities ( = 0.01) and knee-related quality of life ( = 0.003) only promoted among shockwave group. Comparison of two groups merely revealed the superiority of shockwave regarding the knee-related quality of life ( = 0.003) and pain based on VAS score (0.005). Other entities of KOSS and Roles and Maudsley scores were not statistically different between cases and controls ( > 0.05).

CONCLUSION

We found that focused shockwave use can appropriately rehabilitate the knee function and reduce knee osteoarthritis pain. Further studies to assess the best dose and the best location of shockwave administration are strongly recommended.

摘要

背景

骨关节炎是退行性关节炎最常见的形式。迄今为止,针对骨关节炎已推荐了多种管理方法,但其结果并不一致。在本研究中,旨在评估聚焦冲击波疗法治疗膝关节骨关节炎的疗效。

材料与方法

2018 - 2019年在伊朗伊斯法罕对42例膝关节骨关节炎患者(22例病例组和20例对照组,平均年龄58.02±9.90岁)进行了这项随机临床试验。两组均接受外用镇痛药加热敷以及塞来昔布200 mg,共14天。病例组接受冲击波治疗,而对照组接受假冲击波治疗。基于视觉模拟量表(VAS)的疼痛评分、膝关节损伤与骨关节炎结局评分(KOOS)以及罗尔斯和莫兹利评分在基线及12周内进行评估。

结果

两组干预后疾病相关症状(作为KOOS问卷的一部分)均有所改善(<0.05),但组间比较未发现显著差异,而仅冲击波组的日常活动(=0.01)和膝关节相关生活质量(=0.003)有所提高。两组比较仅显示出冲击波在膝关节相关生活质量(=0.003)和基于VAS评分的疼痛方面(0.005)的优势。病例组和对照组之间KOSS以及罗尔斯和莫兹利评分的其他项目无统计学差异(>0.05)。

结论

我们发现使用聚焦冲击波可适当恢复膝关节功能并减轻膝关节骨关节炎疼痛。强烈建议进一步开展研究以评估冲击波给药的最佳剂量和最佳部位。

相似文献

3
Celecoxib for osteoarthritis.塞来昔布用于骨关节炎
Cochrane Database Syst Rev. 2017 May 22;5(5):CD009865. doi: 10.1002/14651858.CD009865.pub2.
6
Stem cell injections for osteoarthritis of the knee.用于膝关节骨关节炎的干细胞注射
Cochrane Database Syst Rev. 2025 Apr 2;4(4):CD013342. doi: 10.1002/14651858.CD013342.pub2.
8
Oral herbal therapies for treating osteoarthritis.用于治疗骨关节炎的口服草药疗法。
Cochrane Database Syst Rev. 2014 May 22;2014(5):CD002947. doi: 10.1002/14651858.CD002947.pub2.

本文引用的文献

2
Extracorporeal shock wave therapy: an update.体外冲击波疗法:最新进展
EFORT Open Rev. 2020 Oct 26;5(10):584-592. doi: 10.1302/2058-5241.5.190067. eCollection 2020 Oct.
9
Aging and osteoarthritis: Central role of the extracellular matrix.衰老与骨关节炎:细胞外基质的核心作用。
Ageing Res Rev. 2017 Nov;40:20-30. doi: 10.1016/j.arr.2017.07.004. Epub 2017 Jul 31.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验