Vahdatpour Babak, Mortazavi Faezeh Sadat, Haghighat Shila, Saleki Mehrjerdi Mohammad, Mortazavi Zahra Sadat
Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Orthopedics, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2025 Jul 21;14:56. doi: 10.4103/abr.abr_202_21. eCollection 2025.
Osteoarthritis is the most common form of degenerative arthritis. To date, varieties of management approaches have been recommended for osteoarthritis, but their outcomes are not consistent. In the current study, it is aimed to assess the efficacy of focused shockwave therapy for the treatment of knee osteoarthritis.
The current randomized clinical trial was conducted on 42 patients (22 cases and 20 controls, with mean age of 58.02 ± 9.90 years) with knee osteoarthritis in 2018-2019, in Isfahan, Iran. Both groups received topical analgesic plus hot pack and celecoxib 200 mg 14d. The cases underwent shockwave therapy, whereas the controls underwent sham shockwave therapy. Pain score based on visual analog scale (VAS), Knee injury and Outcome Osteoarthritis Score (KOOS) and Roles and Maudsley scores were assessed basically and within 12 weeks.
Disease-related symptoms (as a part of KOOS questionnaire) improved following the interventions in both groups ( < 0.05) but the comparison between groups found no significant differences, whereas daily activities ( = 0.01) and knee-related quality of life ( = 0.003) only promoted among shockwave group. Comparison of two groups merely revealed the superiority of shockwave regarding the knee-related quality of life ( = 0.003) and pain based on VAS score (0.005). Other entities of KOSS and Roles and Maudsley scores were not statistically different between cases and controls ( > 0.05).
We found that focused shockwave use can appropriately rehabilitate the knee function and reduce knee osteoarthritis pain. Further studies to assess the best dose and the best location of shockwave administration are strongly recommended.
骨关节炎是退行性关节炎最常见的形式。迄今为止，针对骨关节炎已推荐了多种管理方法，但其结果并不一致。在本研究中，旨在评估聚焦冲击波疗法治疗膝关节骨关节炎的疗效。
2018 - 2019年在伊朗伊斯法罕对42例膝关节骨关节炎患者（22例病例组和20例对照组，平均年龄58.02±9.90岁）进行了这项随机临床试验。两组均接受外用镇痛药加热敷以及塞来昔布200 mg，共14天。病例组接受冲击波治疗，而对照组接受假冲击波治疗。基于视觉模拟量表（VAS）的疼痛评分、膝关节损伤与骨关节炎结局评分（KOOS）以及罗尔斯和莫兹利评分在基线及12周内进行评估。
两组干预后疾病相关症状（作为KOOS问卷的一部分）均有所改善（<0.05），但组间比较未发现显著差异，而仅冲击波组的日常活动（=0.01）和膝关节相关生活质量（=0.003）有所提高。两组比较仅显示出冲击波在膝关节相关生活质量（=0.003）和基于VAS评分的疼痛方面（0.005）的优势。病例组和对照组之间KOSS以及罗尔斯和莫兹利评分的其他项目无统计学差异（>0.05）。
我们发现使用聚焦冲击波可适当恢复膝关节功能并减轻膝关节骨关节炎疼痛。强烈建议进一步开展研究以评估冲击波给药的最佳剂量和最佳部位。
