Milanino R, Cassini A, Franco L, Conforti A, Marrella M, Velo G P
Int J Tissue React. 1985;7(6):469-74.
The concentration and the total content of copper were evaluated in plasma, blood cells, liver and kidney of normal rats and in rats inflamed by intrapleural injection of carrageenan. The experimental disease was followed from zero time up to 10 days after the irritant injection. A statistically significant increase of copper concentration in both plasma and blood cells compartments was measured between zero and 72 h, followed by a prompt return to normal copper levels. On the contrary, copper concentration and total copper content of the liver did not vary throughout the experiment, whereas in the kidney both parameters were found slightly higher than normal 6, 8 and 10 days after the injection of the irritant. These observations are briefly discussed, and proposed as a valuable background to outline new strategies for anti-inflammatory therapy.
评估了正常大鼠以及经胸膜内注射角叉菜胶致炎大鼠的血浆、血细胞、肝脏和肾脏中铜的浓度及总含量。从刺激物注射后的零时刻开始追踪实验性疾病直至10天。在0至72小时之间，血浆和血细胞区室中的铜浓度有统计学意义的显著升高，随后迅速恢复到正常铜水平。相反，肝脏中的铜浓度和总铜含量在整个实验过程中没有变化，而在注射刺激物后的第6、8和10天，肾脏中的这两个参数均略高于正常水平。简要讨论了这些观察结果，并提出将其作为概述抗炎治疗新策略的有价值背景。
