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首例(原称)需手术干预的相关性骨髓炎

The First (Formerly ) -Related Osteomyelitis Requiring Surgical Intervention.

作者信息

Nugraha Patrick, Pan Tzong-Yang, Di Giovine Paul, Mann Nigel, Murphy William

机构信息

Department of Surgery-Plastic and Reconstructive Surgery, The Northern Hospital, Northern Health, Epping, VIC 3076, Australia.

出版信息

Infect Dis Rep. 2025 Aug 4;17(4):94. doi: 10.3390/idr17040094.

Abstract

is a Gram-positive, facultatively anaerobic, rod-shaped bacterium originally isolated from the mucosa and skin of dogs. While it is a part of the normal canine oral flora, it has rarely been implicated in human disease, with only one prior case of cellulitis reported following a dog bite. We present the case of a 57-year-old immunocompetent man who developed osteomyelitis of the left index finger following a delayed presentation after a dog bite. Despite initial conservative management with empirical oral antibiotics, the infection progressed, eventually requiring surgical debridement and the terminalisation of the finger at the proximal interphalangeal joint. Cultures from intraoperative bone specimens yielded the growth of , with no other pathogenic organisms identified on the extended culture. This is the first documented case of -associated osteomyelitis in a human and the first to necessitate a surgical intervention, expanding the known clinical spectrum of this organism. This case underscores the risks of delayed intervention in polymicrobial animal bite wounds and highlights the emerging role of species as opportunistic zoonotic pathogens, particularly in the setting of deep, refractory infections.

摘要

是一种革兰氏阳性、兼性厌氧、杆状细菌,最初从狗的黏膜和皮肤中分离出来。虽然它是犬类正常口腔菌群的一部分,但很少与人类疾病有关,此前仅有一例狗咬伤后发生蜂窝织炎的病例报道。我们报告了一例57岁免疫功能正常的男性病例,他在被狗咬伤后延迟就诊,随后发生了左手食指骨髓炎。尽管最初采用经验性口服抗生素进行保守治疗,但感染仍进展,最终需要手术清创,并在近端指间关节处截指。术中骨标本培养出了 ,在延长培养中未发现其他致病微生物。这是第一例记录在案的人类与 相关的骨髓炎病例,也是第一例需要手术干预的病例,扩大了这种微生物已知的临床谱。该病例强调了对多微生物动物咬伤伤口延迟干预的风险,并突出了 种作为机会性人畜共患病原体的新出现作用,特别是在深部难治性感染的情况下。

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