Nurse-Led Binaural Beat Intervention for Anxiety Reduction in Pterygium Surgery: A Randomized Controlled Trial.

: Anxiety before ophthalmic surgery under local anesthesia may hinder patient cooperation and surgical outcomes. Nurse-led auditory interventions offer a promising non-pharmacological approach to perioperative anxiety management. This study evaluated the effectiveness of superimposed binaural beats (SBBs)-classical music layered with frequency differentials-in reducing anxiety during pterygium surgery with conjunctival autografting. : In this randomized controlled trial, 111 adult patients scheduled for elective pterygium excision with conjunctival autografting under local anesthesia were allocated to one of three groups: SBBs, plain music (PM), or silence (control). A trained perioperative nurse administered all auditory interventions. The patients' anxiety was assessed using the State-Trait Anxiety Inventory-State (STAI-S), and physiological parameters (blood pressure, heart rate, respiratory rate, and oxygen saturation) were recorded before and after surgery. : The SBB group showed significantly greater reductions in their STAI-S scores ( < 0.001), systolic blood pressure ( = 0.011), heart rate ( = 0.003), and respiratory rate ( = 0.009) compared to the PM and control groups. No adverse events occurred. SBBs are a safe, nurse-delivered auditory intervention that significantly reduces perioperative anxiety and supports physiological stability. Their integration into routine nursing care for minor ophthalmic surgeries is both feasible and beneficial. Trial Registration: This study was registered with the Thai Clinical Trials Registry (TCTR) under registration number TCTR20250125002 on 25 January 2025.